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	Zhong (John) Ye Adjunct Assistant Professor of Pathology Office Phone: 202-677-6600 Email: Email Department: Pathology

Education

• M.D., Zhejiang University School of Medicine, 1990
• Master of Science, Iowa State University, 2005
• PhD - Doctor of Philosophy, Iowa State University, 2009

Biography

Zhong (John) Ye MD, PhD is an Adjunct Assistant Professor and Scientist in the Department of Pathology at George Washington University (GW) and Hospital. Prior to joining GW, Dr. Ye was a Senior Clinical Officer at the Department of Personalized Genomic Medicine at Columbia University in New York City; a Faculty Member, Research Instructor and Core Manager of the Circulating Tumor Cell (CTC) Shared Resource in the NCI-designated Sidney Kimmel Cancer Center at Thomas Jefferson University. Dr. Ye completed Postdoctoral Fellowship in the Department of Nutrition at University of California, Davis. His PhD degree in the Department of Food Science and Human Nutrition was from Iowa State University.

Dr. Ye’s clinical practice provides genomics, epigenomics, transcriptomics, oncology and molecular testing; develops leadership in services and projects within Genomic and Molecular Diagnostic Pathology; and conducts translational research of longitudinal and non-invasive monitoring for biomarker discovery.

Clinical Expertise

Dr. Ye’s clinical expertise focuses on diagnostic genomic assays for Next Generation Sequencing (NGS) including targeted panel sequencing, whole exome sequencing, whole-genome sequencing and whole genome bisulfite sequencing (WGBS) and single cell DNA/RNA sequencing from formalin-fixed and paraffin-embedded (FFPE) section dissociation, circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) liquid biopsy in cancer patients. He also provides microsatellite instability and Fluorescence In Situ Hybridization services for molecular pathology.

Dr. Ye performs extensive expertise in NGS workflows and techniques with library preparation for sequencing with Illumina operation including MiSeq and NextSeq and workflows development. Dr. Ye conducts technically validated, clinical diagnostic genomic assays under Clinical Laboratory Improvement Amendments (CLIA) regulations using his expertise in molecular biology and cell biology techniques. He involved in grant preparation, manuscript writing and scientific journal review; participated scientific conferences, association and scientific communities; and received many certificates, academic awards and honors.

Research

Dr. Ye’s research is mainly focused on next-generation sequencing (NGS)-based technologies including whole genome, exome sequencing, and targeted sequencing to uncover novel therapeutic targets and cancer biomarkers discovery including:

Population-based approach for single cell NGS analysis using genomic and transcriptomic profiling in cancer prognostication and prediction; circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) liquid biopsy in cancer patients. Progression and underlying molecular mechanisms using NGS in tumor. MicroRNA-related molecular markers, whole exome sequencing, and small non-coding RNA next-generation sequencing of cancer risk and clinical outcome.

Dr. Ye has more than 60 publications including top journals with CTCs and ctDNA in the European Journal of Cancer; the novel genetic susceptibility loci for inflammatory breast cancer by whole exome sequencing in Annals of Oncology and JNCCN.

Publications

Luo R, Chong W, Wei Q, Zhang Z, Wang C, Ye Z. et al. Whole-exome sequencing identifies somatic mutations and intratumor heterogeneity in inflammatory breast cancer. NPJ Breast Cancer. 2021 Jun 1; 7 (1):72.

Ye Z, Wang C, Wan S, Mu Z, Zhang Z, Abu-Khalaf MM, Fellin FM, Silver DP, Neupane M, Jaslow RJ, Bhattacharya S, Tsangaris TN. et al. Association of clinical outcomes in metastatic breast cancer patients with circulating tumour cell and circulating cell-free DNA. European Journal of Cancer. 2019 Jan; 106:133-143.

Ye Z, Wang C, Guo L, Palazzo J, Han Z, Lai Y, Jiang J, Posey J, BasuMallick A, Li B, Jiang L, Yang H. A routine laboratory data-based model for predicting recurrence after curative resection of stage II colorectal cancer. J Natl Compr Canc Netw. 2018 Oct; 16 (10):1183-1192.

Wei Q, Ye Z (co-first author), Zhong X, Li L, Wang C, Myers RE, Palazzo JP, Fortuna D, Yan A, Waldman SA, Chen X, Posey JA. et al. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis. Annals of Oncology, Volume 28, Issue 9, 2017, 2135–2141.

Zhu Z, Li L, Ye Z, Fu T, Du Y, Shi A, Wu D, Li K, Zhu Y, Wang C, Fan Z. Prognostic value of routine laboratory variables in prediction of breast cancer recurrence. Sci Rep, 2017, 7 (1): 8135.

Wan S, Hann HW, Ye Z, Hann RS, Lai Y, Wang C, Li L, Myers RE, Li B, Xing J, Yang H. Prospective and longitudinal evaluations of telomere length of circulating DNA as a risk predictor of hepatocellular carcinoma in HBV patients. Carcinogenesis, 2017, 38 (4): 439-446.

Wang C, Mu Z, Chervoneva I, Austin L, Ye Z, Rossi G, Palazzo JP, Sun C, Abu-Khalaf M, Myers RE, Zhu Z, Ba Y, Li B, Hou L, Cristofanilli M, Yang H. Longitudinally collected CTCs and CTC-clusters and clinical outcomes of metastatic breast cancer. Breast Cancer Res Treat, 2017, 161 (1): 83-94.

Wang C, Hann HW, Ye Z (co-first author), Hann RS, Wan S, Ye X, Block PD, Li B, Myers RE, Wang X, Juon HS, Civan J, Chang M, Bae HS, Xing J, Yang H. Prospective evidence of a circulating microRNA signature as a non-invasive marker of hepatocellular carcinoma in HBV patients. Oncotarget, 2016.

Mu Z, Benali-Furet N, Znaty A, Ye Z, Paolillo C, Wang C, Austin L, Rossi G, Fortina P, Yang H, Cristofanilli M. Detection and characterization of circulating tumor associated cells in metastatic breast cancer. Int J Mol Sci, 2016, 17 (10): E1665.

Li L, Hann HW, Ye X, Myers RE, Ye Z, Li B, Xing J, Yang H. Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection. Sci Rep, 2016, 6: 23992.

Ye Z, Arumugam V, Haugabrooks E, Williamson P, Hendrich S. Soluble dietary fiber (Fibersol-2) decreased hunger and increased satiety hormones in humans when ingested with a meal. Nutr Res. 2015 May; 35(5):393-400.

Wang C, Hann HW, Wan S, Myers RE, Ye Z, Xing J, Yang H. Circulating mitochondrial DNA content associated with the risk of liver cirrhosis: a nested case-control study. Dig Dis Sci, 2015, 60 (6): 1707-1715.

Mu Z, Wang C, Ye Z, Austin L, Civan J, Hyslop T, Palazzo JP, Jaslow R, Li B, Myers RE, Jiang J, Xing J, Yang H, Cristofanilli M. Prospective assessment of the prognostic value of circulating tumor cells and their clusters in patients with advanced-stage breast cancer. Breast Cancer Res Treat, 2015, 154 (3): 563-571.

Lai Y, Ye Z, Civan JM, Wang C, Cristofanilli M, Mu Z, Austin L, Palazzo JP, Myers RE, Yang H. The effects of erythropoiesis-stimulating agents on the short-term and long-term survivals in metastatic breast cancer patients receiving chemotherapy: a SEER population-based study. Breast Cancer Res Treat, 2015, 153 (2): 407-416

Lai Y, Palazzo JP, Cristofanilli M, Myers RE, Li B, Ye Z, Xing J, Yang H. Erythropoiesis stimulating agents and clinical outcomes of invasive breast cancer patients receiving cytotoxic chemotherapy. Breast Cancer Res Treat. 2014 Nov; 148(1):175-85.

Jin X, Zhang KJ, Guo X, Myers R, Ye Z, Zhang ZP, Li XF, Yang HS, Xing JL. Fatty Acid Synthesis Pathway Genetic Variants and Clinical Outcome of Non-Small Cell Lung Cancer Patients after Surgery. Asian Pac J Cancer Prev. 2014; 15 (17):7097-103.

Ye Z, Palazzo JP, Lin L, Lai Y, Guiles F, Myers RE, Han J, Xing J, Yang H. Postoperative hyperphosphatemia significantly associates with adverse survival in colorectal cancer patients. J Gastroenterol Hepatol. 2013 Sep; 28 (9):1469-75.

Ye Z, Hong CO, Lee K, Hostetter J, Wannemuehler M and Hendrich S. Plasma caffeic acid is associated with statistical clustering of the anti-colitic efficacy of caffeic acid in dextran sulfate sodium-treated mice. Journal of Nutrition, 2011 Nov; 141(11):1989-95.

Qiang Z, Ye Z, Hauck C, Murphy PA, McCoy JA, Widrlechner MP, Reddy MB, Hendrich S. Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers. J Ethnopharmacol. 2011 Oct 11;137 (3):1107-12. [Full Text].

Qiang Z, Lee S, Ye Z, Wu X, Hendrich S. Artichoke extract lowered plasma cholesterol and increased fecal bile acids in golden Syrian hamsters. Phytother Res. 2011 Dec 20.

Ye Z, Liu Z, Henderson A, Lee K, Hostetter J, Wannemuehler M, Hendrich S. Increased CYP4B1 mRNA Is Associated with the Inhibition of Dextran Sulfate Sodium-Induced Colitis by Caffeic Acid in Mice. Exp Biol Med. 2009 Mar 23. [Full Text] [PDF] [Science Daily].

Lee SO, Renouf M, Ye Z, Murphy PA, Hendrich S. Isoflavone glycitein diminished plasma cholesterol in female golden Syrian hamsters. J Agric Food Chem. 2007 Dec 26; 55 (26):11063-7. Epub 2007 Nov 27.

Ye Z, Renouf M, Lee SO, Hauck CC, Murphy PA, Hendrich S. High urinary isoflavone excretion phenotype decreases plasma cholesterol in golden Syrian hamsters fed soy protein. Journal of Nutrition 2006 Nov;136 (11):2773-8. Full Text [PDF].

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

• None