Yanfen Hu IBS Director Professor of Anatomy and Cell Biology Office Phone: 202-994-8888 Email: Email Department: Anatomy and Cell Biology

Education

• BS, Fudan University, PRC, 1985
• PhD, University of California Berkeley, 1992

Research

Review additional publications prior to 2014

Publications

Wu B, Sun X, Yuan B, Ge F, Gupta HB, Chiang HC, Li J, Hu Y, Curiel TJ, Li R. PPAR? inhibition boosts efficacy of PD-L1 Checkpoint Blockade Immunotherapy against Murine Melanoma in a sexually dimorphic manner. Int J Biol Sci. 2020;16(9):1526-1535. doi: 10.7150/ijbs.42966. eCollection 2020. PubMed PMID: 32226299; PubMed Central PMCID: PMC7097912.

Chiang HC, Zhang X, Li J, Zhao X, Chen J, Wang HT, Jatoi I, Brenner A, Hu Y, Li R. BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells. Nucleic Acids Res. 2019 Jun 4;47(10):5086-5099. doi: 10.1093/nar/gkz262. PubMed PMID: 30982901; PubMed Central PMCID: PMC6547407.

Zhang X, Wang Y, Chiang HC, Hsieh YP, Lu C, Park BH, Jatoi I, Jin VX, Hu Y, Li R. BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells. Breast Cancer Res. 2019 Apr 17;21(1):51. doi: 10.1186/s13058-019-1132-1. PubMed PMID: 30995943; PubMed Central PMCID: PMC6472090.

Wu B, Sun X, Gupta HB, Yuan B, Li J, Ge F, Chiang HC, Zhang X, Zhang C, Zhang D, Yang J, Hu Y, Curiel TJ, Li R. Adipose PD-L1 Modulates PD-1/PD-L1 Checkpoint Blockade Immunotherapy Efficacy in Breast Cancer. Oncoimmunology. 2018;7(11):e1500107. doi: 10.1080/2162402X.2018.1500107. eCollection 2018. PubMed PMID: 30393583; PubMed Central PMCID: PMC6209395.

Sun X, Gupta K, Wu B, Zhang D, Yuan B, Zhang X, Chiang HC, Zhang C, Curiel TJ, Bendeck MP, Hursting S, Hu Y, Li R. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. J Biol Chem. 2018 Feb 23;293(8):2841-2849. doi: 10.1074/jbc.RA117.000672. Epub 2018 Jan 3. PubMed PMID: 29298894; PubMed Central PMCID: PMC5827455.

Chiang HC, Zhang X, Zhao X, Zhang C, Chen J, Garza P, Smith S, Ludwig T, Baer RJ, Li R, Hu Y. Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development. Sci Rep. 2018 Feb 9;8(1):2731. doi: 10.1038/s41598-018-21044-2. PubMed PMID: 29426838; PubMed Central PMCID: PMC5807304.

Zhang X, Chiang HC, Wang Y, Zhang C, Smith S, Zhao X, Nair SJ, Michalek J, Jatoi I, Lautner M, Oliver B, Wang H, Petit A, Soler T, Brunet J, Mateo F, Angel Pujana M, Poggi E, Chaldekas K, Isaacs C, Peshkin BN, Ochoa O, Chedin F, Theoharis C, Sun LZ, Curiel TJ, Elledge R, Jin VX, Hu Y, Li R. Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. Nat Commun. 2017 Jun 26;8:15908. doi: 10.1038/ncomms15908. PubMed PMID: 28649985; PubMed Central PMCID: PMC5490191.

Yuan B, Cheng L, Gupta K, Chiang HC, Gupta HB, Sareddy GR, Wang D, Lathrop K, Elledge R, Wang P, McHardy S, Vadlamudi R, Curiel TJ, Hu Y, Ye Q, Li R. Tyrosine phosphorylation regulates ER? ubiquitination, protein turnover, and inhibition of breast cancer. Oncotarget. 2016 Jul 5;7(27):42585-42597. doi: 10.18632/oncotarget.10018. PubMed PMID: 27323858; PubMed Central PMCID: PMC5173158.

Nair SJ, Zhang X, Chiang HC, Jahid MJ, Wang Y, Garza P, April C, Salathia N, Banerjee T, Alenazi FS, Ruan J, Fan JB, Parvin JD, Jin VX, Hu Y, Li R. Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. Nat Commun. 2016 Mar 4;7:10913. doi: 10.1038/ncomms10913. PubMed PMID: 26941120; PubMed Central PMCID: PMC4785232.

Chiang HC, Elledge R, Larson P, Jatoi I, Li R, Hu Y. Effects of Radiation Therapy on Breast Epithelial Cells in BRCA1/2 Mutation Carriers. Breast Cancer (Auckl). 2015;9:25-9. doi: 10.4137/BCBCR.S26774. eCollection 2015. PubMed PMID: 26052229; PubMed Central PMCID: PMC4454133.

Pan H, Zhao X, Zhang X, Abouelsoud M, Sun J, April C, Amleh A, Fan JB, Hu Y, Li R. Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B. PLoS One. 2015;10(5):e0127422. doi: 10.1371/journal.pone.0127422. eCollection 2015. PubMed PMID: 26010750; PubMed Central PMCID: PMC4444357.

Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, Hu Y. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14(3):437-48. doi: 10.4161/15384101.2014.972901. PubMed PMID: 25659039; PubMed Central PMCID: PMC435323

Ghosh S, Gu F, Wang CM, Lin CL, Liu J, Wang H, Ravdin P, Hu Y, Huang TH, Li R. Genome-wide DNA methylation profiling reveals parity-associated hypermethylation of FOXA1. Breast Cancer Res Treat. 2014 Oct;147(3):653-9. doi: 10.1007/s10549-014-3132-2. Epub 2014 Sep 19. PubMed PMID: 25234841; PubMed Central PMCID: PMC4181377.

Yuan B, Cheng L, Chiang HC, Xu X, Han Y, Su H, Wang L, Zhang B, Lin J, Li X, Xie X, Wang T, Tekmal RR, Curiel TJ, Yuan ZM, Elledge R, Hu Y, Ye Q, Li R. A phosphotyrosine switch determines the antitumor activity of ER?. J Clin Invest. 2014 Aug;124(8):3378-90. doi: 10.1172/JCI74085. Epub 2014 Jun 24. PubMed PMID: 24960160; PubMed Central PMCID: PMC4109526.

Pan H, Qin K, Guo Z, Ma Y, April C, Gao X, Andrews TG, Bokov A, Zhang J, Chen Y, Weintraub ST, Fan JB, Wang D, Hu Y, Aune GJ, Lindsey ML, Li R. Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014 Apr 10;7(1):79-85. doi: 10.1016/j.celrep.2014.02.028. Epub 2014 Mar 20. PubMed PMID: 24656816; PubMed Central PMCID: PMC4277258.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

• None