Victoria Mann Assistant Research Professor of Microbiology, Immunology, and Tropical Medicine Office Phone: 202-994-3532 Email: Email Department: Microbiology, Immunology, and Tropical Medicine

Education

• B.S., College of Charleston, 1983
• MSPH, University of North Carolina, Chapel Hill, 1984
• PhD, University of North Carolina, Chapel Hill, 1990

Biography

Dr. Mann, a graduate - MSP and PhD degrees - of the University of North Carolina, Chapel Hill, completed post doctoral training at the NIAID's Laboratory of Parasitic Diseases, NIH, Bethesda, Maryland. She has held scientific appointments at the University of New South Wales, Sydney, Australia, the Queensland Institute of Medical Research, Brisbane, Australia and Tulane University School of Public Health & Tropical Medicine, New Orleans, Louisiana. Dr. Mann's doctoral dissertation dealt with transcription in African trypanosomes and her postdoc studies with cell biology of trypanosomatid and malaria. She is expert in cell and molecular biology of protozoan, helminth and viral pathogens, and is active in mentoring the graduate studies in this laboratory.

Research

The research in Dr. Mann's (and Brindley's) laboratory deals with neglected tropical diseases. Specifically, Dr. Mann is undertaking molecular biological investigations dealing with development of tools for functional genomics of schistosomes. These studies include development retroviral constructs to transfer report genes into cultured schistosomes. In addition, she is carrying out studies dealing with the food borne fluke, Opisthorchis viverrini, an enigmatic helminth parasite that causes bile duct cancer in many chronically infected persons. (Opisthorchiasis is endemic in Thailand and Laos.) Current research is our lab focuses on expression of prospective vaccine candidate gene of O. viverrini, and on molecular carcinogenesis studies of O. viverrini antigens.

Publications

Mann, V.H., Morales, M.E., Rinaldi, G., Brindley, P.J. (2010) Culture for genetic manipulation of developmental stages of Schistosoma mansoni. Parasitology 137, 451-462

Kines, K.J., Rinaldi, G., Okatcha, T.I., Morales, M.E., Mann, V.H., Tort, J.F., Brindley, P.J. (2010) Electroporation facilitates introduction of reporter transgenes and virions into schistosome eggs. PLoS Neglected Tropical Diseases 4(2): e593

Pinlaor, P., Kaepitoon, N., Laha, T., Sripa, B., Kaewkes, S., Morales, M.E., Mann, V.H., Parriott, S.K., Suttiprapa, S., Robinson, M.W., To, J., Dalton, J.P., Loukas, A., Brindley, P.J. (2009) Cathepsin F cysteine protease of Opisthorchis viverrini. PLoS Neglected Tropical Diseases 3(3): e398. PMC2654340

Kines, K.J., Morales, M.E., Mann, V.H., Gobert, G.N., Brindley, P.J. (2008) Integration of reporter transgenes into Schistosoma mansoni chromosomes mediated by pseudotyped murine leukemia virus. The FASEB Journal 22, 2936-2948.Â

Mann, V.H., Morales, M.E., Kines, K.J., Brindley, P.J. (2008) Transgenesis of schistosomes: approaches using mobile genetic elements. Parasitology 134, 1-13.

Copeland, C.S., Mann, V.H., Brindley, P.J. (2007) Both sense and antisense strands of the LTR of the Schistosoma mansoni Pao-like retrotransposon Sinbad drive luciferase expression. Molecular Genetics and Genomics 277, 161-170.

Morales, M.E., Mann, V.H., Kines, K.J., Gobert, G.N., Fraser, M.J. Jr., Kalinna, B.H., Correnti, J.M., Pearce, E.J., Brindley, P.J. (2007) piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. The FASEB Journal 21, 3479-3489.

Kines, K.J*., Mann, V.H*., Morales, M.E., Shelby, B.F., Kalinna, B.H., Gobert, G.N., Chirgwin, S.R., Brindley, P.J. (2006) Transduction of Schistosoma mansoni by vesicular stomatitis virus glycoprotein-pseudotyped Moloney murine leukemia retrovirus. Experimental Parasitology 112, 209-220. *Equal contribution.

Copeland, C.S., Mann, V.H., Morales, M.E., Kalinna, B.H. and Brindley, P.J. (2005) The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements. BMC Evolutionary Biology 5:20.

McCarthy, E., Stack, C., Donnelly, S.M., Doyle, S., Mann, V.H., Brindley, P.J., Stewart, M., Day, T.A., Maule, A.G., and Dalton, J.P. (2004) Leucine aminopeptidase on the human blood flukes, Schistosoma mansoni and Schistosoma japonicum. International Journal of Parasitology 34, 703-714.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

• None