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Pedro Gazzinelli Guimaraes Pedro Gazzinelli Guimaraes
Assistant Professor of Microbiology, Immunology, and Tropical Medicine

Office Phone: 202-994-0818
Email: Email
Department: Microbiology, Immunology, and Tropical Medicine

Education

  • Bachelor of Science, FUMEC University, Brazil, 2008
  • Master of Science, Federal University of Minas Gerais, 2010
  • PHD, Federal University of Minas Gerais, 2014

Biography

Dr. Gazzinelli-Guimaraes’ research program has been focused on the regulation of the immune response to helminth parasitic infections and to the pathogenesis of allergic diseases. The Gazzinelli Lab has a specific interest in understanding the plasticity and specificity of circulating peripheral and tissue-resident effector Th2 cells driven by helminth antigens and/or allergens, as well as to understand the role of the effector Th2 subsets in the establishment of tissue Type-2-mediated inflammation using both mouse models and human studies. These studies aim to identify potential targets for the development of selective immunotherapy that could prevent chronic helminth infection or that could diminish allergic inflammation.

Research

• Interaction between allergen- and helminth-driven type-2 immune responses
• Biomarkers for helminth antigens- and allergens-specific human Th2 cells subsets
• Multiomic profiling and TCR repertoire diversity of effector Th2 cells in the context of allergic diseases and helminth infections in both human studies and experimental models
• Influence of helminth infections on the regulation of the immune response of allergic individuals
• Genetic determinants of type-2 lung inflammation

Publications

Lopes CA, Wang J, Liffner B, Absalon S, Gazzinelli-Guimaraes PH. Ascaris Mouse Model Protocols: Advancing Research on Larval Ascariasis Biology. Current Protocols.

Gazzinelli-Guimaraes PH, Brittany D, Swanson P, Lack J, Roederer M, Nutman T. Single- cell molecular signature of pathogenic T helper subsets in type 2– associated disorders in humans. JCI Insight. doi.org/10.1172/jci.insight.177720.

Amaral E, Namasivayam S, Queiroz A, Fukutani E, Hilligan K, Aberman K, Fisher L, Bomfim C, Kauffman K, Buchanan J, Santuo L, Gazzinelli-Guimaraes PH, Costa D, Teixeira M, Barreto-Duarte B, Gurgel-Rocha C, Barber D, Wilkinson R, Kramnik I, Igarashi K, Scriba T, Mayer-Barber K, Andrade B, Sher A. BACH1 is a central regulator of glutathione metabolism, cellular necrosis and host resistance in Mycobacterium tuberculosis infection. Nature Microbiology. 2024.

Kupritz J, Angelova A, Nutman TB, Gazzinelli-Guimaraes PH. Helminth-Induced Human Gastrointestinal Dysbiosis: a Systematic Review and Meta-Analysis Reveals Insights into Altered Taxon Diversity and Microbial Gradient Collapse. mBio. 2021 Dec 21;12(6):e0289021.

Gazzinelli-Guimaraes PH, Bennuru S, de Queiroz Prado R, Ricciardi A, Sciurba J, Kupritz J, Moser M, Kamenyeva O, Nutman TB. House dust mite sensitization drives cross-reactive immune responses to homologous helminth proteins. PLoS Pathog. 2021 Mar 2;17(3):e1009337.

Lee SH, Chaves MM, Kamenyeva O, Gazzinelli-Guimaraes PH, Kang B, Pessenda G, Passelli K, Tacchini-Cottier F, Kabat J, Jacobsen EA, Nutman TB, Sacks DL. M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis. Sci Immunol. 2020 Apr 10;5(46):eaaz4415.

Gazzinelli-Guimaraes PH, de Queiroz Prado R, Ricciardi A, Bonne-Année S, Sciurba J, Karmele EP, Fujiwara RT, Nutman TB. Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development. J Clin Invest. 2019 Aug 5;129(9):3686-3701.

Gazzinelli-Guimaraes PH, Nutman TB. Helminth parasites and immune regulation. F1000Res. 2018 Oct 23;7:F1000 Faculty Rev-1685.

Gazzinelli-Guimarães PH, Bonne-Année S, Fujiwara RT, Santiago HC, Nutman TB. Allergic Sensitization Underlies Hyperreactive Antigen-Specific CD4+ T Cell Responses in Coincident Filarial Infection. J Immunol. 2016 Oct 1;197(7):2772-9. doi: 10.4049/jimmunol.1600829. Epub 2016 Aug 26. PMID: 27566825; PMCID: PMC5026971.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None