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Marc Siegel Marc Siegel
Associate Professor of Medicine

Office Phone: 202-741-2234
Email: Email
Department: Medicine


  • BA, Georgetown University, 1992
  • MD, Georgetown University School of Medicine, 1998


Dr. Marc Siegel received his B.A. and M.D. degrees from Georgetown University, graduating cum laude and as a member of Alpha Omega Alpha. He completed his residency training at Georgetown University Medical Center and subsequently started his own internal medicine practice in York, Maine. In 2007 Dr. Siegel started his infectious diseases fellowship at George Washington University. He joined the Division of Infectious Disease as a faculty member in 2009. His areas of clinical interest include HIV preexposure prophylaxis (PrEP) for the prevention of HIV transmission, chronic hepatitis C, and prevention of COVID-19.

Dr. Siegel has served as the Principal Investigator for multiple HIV and HCV treatment clinical trials. He has been the Medical Lead on six HIV Prevention Trials Network (HPTN) clinical trials looking at various forms of PrEP in men and women at risk of HIV infection. He is currently the Principal Investigator for a trial looking at using a monoclonal antibody in patients with severe COVID-19 and is a Co-Investigator of the COVE trial looking at the efficacy of the Moderna coronavirus vaccine which starting enrolling participants at GW in August 2020.


  • Infectious Diseases


View publications by this faculty member.

Magnus M, Edwards E, Dright A, Gilliam L, Brown A, Levy M, Sikka M, Siegel M, Criss V, Watson CC, Machtinger E, Kuo I. Development of a telehealth intervention to promote care-seeking among transgender women of color in Washington, DC. Public Health Nursing

Desrosiers A, Levy M, Dright A, Zumer M, Jallah N, Kuo I, Magnus M, Siegel M. A Randomized Controlled Pilot Study of a Culturally-Tailored Counseling Intervention to Increase Uptake of HIV Pre-exposure Prophylaxis Among Young Black Men Who Have Sex with Men in Washington, DC. AIDS and Behavior

Tolley E, Zangeneh S, Chau G, Eron J, Grinsztejn B, Humphries H, Liu A, Siegel M, Maseko B, Panchia R, Li S, Cottle L, Rinehart A, Margolis D, Jennings A, McCauley M, Landovitz R. Acceptability of Long-Acting Injectable Cabotegravir (CAB LA) in HIV-uninfected Individuals: HPTN 077. AIDS & Behavior

Siegel M, Borkowska A, Roberts A, Parenti D, Dubrovsky L, Simmens S, Sviridov D, Simon G, Fitzgerald M, Bukrinsky M. HIV infection induces structural and functional changes in High Density Lipoproteins. Publication pending, Atherosclerosis

Toma I, Siegel M, Keiser J, Yakovleva A, Kim A, Davenport L, Devaney J, Hoffman E, Alsubail R, Crandall K, Castro-Nallar E, Perez-Losada M, Hilton S, Chawla L, McCaffrey T, Simon G. Single-Molecule Long Read 16S Sequencing to Characterize the Lung Microbiome from Mechanically Ventilated Patients with Suspected Pneumonia. J Clin Microbiol. 2014 Nov;52(11):3913-21

Byrd A, Perez-Rogers J, Manimaran S, Castro-Nallar E, Toma I, McCaffrey T, Siegel M, Benson G, Crandall K, Johnson W. Clinical PathoScope: Rapid alignment and filtration for accurate pathogen identification in clinical samples using unassembled sequencing data. BMC Bioinformatics. 2014 Aug 4;15(1):262

Siegel M, Simon G. Is Human Immunodeficiency Virus Infection a Risk Factor for Strongyloides stercoralis Hyperinfection and Dissemination? PLoS Negl Trop Dis 2012;6(7): e1581.

Siegel M, Parenti D, Simon G. Atrial-Esophageal Fistula after Atrial Radiofrequency Catheter Ablation. Clin Infect Dis. 2010 Jul 1;51(1):73-6.

Siegel M, Kennedy L, Rexroth K, Lankford M, Turner M, McKnight A, Cummins S, Benator D, Kan V. Better But Not Ideal Acceptance of Routine Inpatient HIV Point-of-Care Testing among Veterans in a High Prevalence Area. J Acquir Immune Defic Syndr. 2010 May 20.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None