Marc Siegel Marc Siegel
Professor of Medicine

Office Phone: 202-741-2234
Email: Email
Department: Medicine

Biography

Dr. Marc Siegel received his B.A. and M.D. degrees from Georgetown University, graduating cum laude and as a member of Alpha Omega Alpha. He completed his residency training at Georgetown University Medical Center and subsequently started his own internal medicine practice in York, Maine. In 2007 Dr. Siegel started his infectious diseases fellowship at George Washington University. He joined the Division of Infectious Disease as a faculty member in 2009 and is currently the Director of the Division of Infectious Diseases and a Professor of Medicine. His areas of clinical interest include novel therapies for treatment of HIV, Preexposure Prophylaxis (PrEP) for the prevention of HIV transmission, chronic hepatitis B and C, and prevention of COVID-19.

Dr. Siegel has served as the Principal Investigator for multiple HIV and HCV treatment clinical trials. He has been the Medical Lead on eight HIV Prevention Trials Network (HPTN) clinical trials looking at various forms of PrEP in men and women at risk of HIV infection. He is currently the Principal Investigator for a trial looking at using a long-acting injectable HIV medication to prevent HIV in women at risk of HIV acquisition.

Training

  • BA, Georgetown University, 1992
  • MD, Georgetown University School of Medicine, 1998
  • Internal Medicine Residency, Georgetown University Medical Center, 1998-2001
  • Infectious Diseases Fellowship, George Washington University Hospital, 2007-2009

Expertise

  • Novel therapies for treatment of HIV
  • Preexposure Prophylaxis (PrEP) for the prevention of HIV transmission
  • Treatment of chronic hepatitis B and C
  • Prevention of COVID-19

Research

  1. Yellin H, Levy M, Magnus M, Kuo I, Siegel M. HIV risk perception, willingness to use PrEP, and PrEP uptake among young men who have sex with men in Washington, DC. AIDS Behav. 2023 Sep;27(9):2844-2854. PMID: 36807246
  2. Lucar J, Roberts A, Saardi K, Yee R, Siegel M, Palmore T. Monkeypox Virus-Associated Severe Proctitis Treated with Oral Tecovirimat: A Report of Two Cases. Ann Intern Med. 2022 Nov;175(11):1626-1627. PMID: 35981225
  3. Millan S, Ali R, Sanfilippo E, Siegel M, Cardis MA, Saardi KM. "Knife-cut" intertriginous ulcers related to herpes simplex virus in three patients. Dermatol Online J. 2022 Aug 15;28(4). PMID: 36259865
  4. Makhoul J, Uppal S, Siegel M. Double Trouble: Concomitant Unmasking and Paradoxical Immune Reconstitution Inflammatory Syndrome in a Patient with Newly Diagnosed HIV. ID Cases. 2022 Mar 25;28:e01482. PMID: 35392599
  5. Sjaarda A, Bernstein A, Sparks A, Saber S, Siegel M. Comparison of Weight Gain after Antiretroviral Switch to Integrase Strand Transfer Inhibitor or Tenofovir Alafenamide-Based Therapy. Infection. 2022 Apr;50(2):407-412. PMID: 34449049
  6. Corey L, Gilbert PB, Juraska M, et al; HVTN 704/HPTN 085 and HVTN 703/HPTN 081 Study Teams. Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition. N Engl J Med. 2021 Mar 18;384(11):1003-1014. PMID: 33730454; PMCID: PMC8189692
  7. Baden LR, El Sahly HM, Essink B, et al, COVE Study Group. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine.  N Engl J Med. 2021 Feb 4;384(5):403-416. PMID: 33378609
  8. Weinreich DM, Sivapalasingam S, Norton T, et al, Trial Investigators. REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N Engl J Med. 2021 Jan 21;384(3):238-251. PMID: 33332778
  9. Harold R, Roberts A, Siegel M, Akselrod H, Simon G. Diagnostic dilemma: Ureaplasma septic polyarthritis in a 23-year-old female with Neuromyelitis optica receiving rituximab. BMJ Case Rep. 2021 Feb 1;14(2):e237916. PMID: 33526524
  10. Kobayashi T, Marra A, Schweizer M, Ten P, Wu C, Alzunitan M, Salinas J, Siegel M, Farmakiotis D, Auwaerter P, Healy H, Diekema D. Impact of Infectious Disease Consultation in patients with Candidemia: A Retrospective study, Systematic Literature Review and Meta-analysis. Open Forum Infect Dis. 2020 Aug 3;7(9):ofaa270. PMID: 32904995.
  11. Torres-Miranda D, Akselrod H, Karsner R, Secco A, Silva-Cantillo D, Siegel M, Roberts A, Simon G. Use of BioFire FilmArray gastrointestinal PCR panel associated with reductions in antibiotic use, time to optimal antibiotics, and length of stay. BMC Gastroenterol 2020 Jul 29;20(1):246 PMID: 32727381.
  12. Tolley E, Zangeneh S, Chau G, Eron J, Grinsztejn B, Humphries H, Liu A, Siegel M, Maseko B, Panchia R, Li S, Cottle L, Rinehart A, Margolis D, Jennings A, McCauley M, Landovitz R. Acceptability of Long-Acting Injectable Cabotegravir (CAB LA) in HIV-uninfected Individuals: HPTN 077. AIDS & Behavior 2020 Sep;24(9):2520-2531. PMID: 32052214.
  13. Magnus M, Edwards E, Dright A, Gilliam L, Brown A, Levy M, Sikka M, Siegel M, Criss V, Watson CC, Machtinger E, Kuo I. Development of a telehealth intervention to promote care-seeking among transgender women of color in Washington, DC. Public Health Nurs. 2020;00:1–10. https:// doi.org/10.1111/phn.12709. PMID: 32017202.
  14. Shelton A, Giurgea L, Moshgriz M, Siegel M, Akselrod H. A case of Mycobacterium goodii infection related to an indwelling catheter placed for the treatment of chronic symptoms attributed to Lyme disease. Infect Dis Rep. 2019 Sep 18;11(2):8108. PMID: 31579470
  15. Desrosiers A, Levy M, Dright A, Zumer M, Jallah N, Kuo I, Magnus M, Siegel M. A Randomized Controlled Pilot Study of a Culturally-Tailored Counseling Intervention to Increase Uptake of HIV Pre-exposure Prophylaxis Among Young Black Men Who Have Sex with Men in Washington, DC.  AIDS and Behavior, 2019 Jan;23(1):105-115. PMID:30171452.
  16.  Torres-Mirranda D, Moshgriz M, Siegel M. Streptobacillus moniliformis Mitral Valve Endocarditis and Septic Arthritis: The Challenges of Diagnosing Rat-Bite Fever Endocarditis. Infect Dis Rep. 2018 Sep 24;10(2):7731. PMID:30344968.
  17. Magnus M, Edwards E, Dright A, Gilliam L, Brown A, Levy M, Sikka N, Siegel M, Criss V, Watson C, Machtinger E, Kuo I. A Feasibility Study of a Telehealth Intervention on Health Care Service Utilization among Transgender Women of Color in Washington, DC. Applied Clinical Informatics Open Access 2017 Dec; 02(01): e1-e9.
  18. Lucar J, Hart R, Rayeed N, Terzian A, Weintrob A, Siegel M, Parenti D, Squires L, Williams R, Benator D. Sexually Transmitted Infections among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data from the DC Cohort. Open Forum Infectious Diseases 2018 Jan 24;5(2). PMID:29479550.
  19. Zhang Y, Clarke W, Marzinke M, Piwowar-Manning E, Beauchamp G, Breaud A, Hendrix C, Cloherty G, Emel L, Rose S, Hightow-Weidman L, Siegel M, Shoptaw M, Fields S, Wheeler D, Eshleman S. Evaluation of a multi-drug assay for monitoring adherence to a regimen for HIV pre-exposure prophylaxis in a clinical study (HIV Prevention Trials Network 073). Antimicrobial Agents and Chemotherapy. 2017 Jun 27;61(7). pii: e02743-16. PMID: 28438932
  20. Gulick R, Wilkin T, Chen Y, Landovitz R, Amico K, Young A, Richardson P, Marzinke M, Hendrix C, Eshleman S, McGowan I, Cottle L, Andrade A, Marcus C, Klingman K, Chege W, Rinehart A, Rooney J, Andrew P, Salata R, Siegel M, Magnus M, Farley J, Liu A, Frank I, Ho K Santana J, Stekler J, McCauley M, Mayer K. Safety and tolerability of maraviroc-containing regimens to prevent HIV infection in women: a phase 2 randomized trial.  Annals of Internal Medicine. 2017 Sep 19;167(6):384-393. PMID:28828489.
  21. Geier C, Davis J, Siegel M. Severe Human Monocytic Ehrlichiosis presenting with Altered Mental Status and Seizures. BMJ Case Reports, 2016 Oct 6;2016. pii: bcr2016215967 PMID: 27758794
  22. Blair P, Moshgriz M, Keiser J, Siegel M. Mycobacterium fortuitum Empyema Associated with an Indwelling Pleural Catheter: Case report and Review of the Literature. J Infect Chemother. 2017 Mar;23(3):177-179. PMID:27890417
  23. Siegel M, Ghafouri S, Ajmera R, Simon G. Immune Reconstitution Inflammatory Syndrome, Human Herpesvirus-8 Viremia and HIV-Associated Multicentric Castleman's Disease. Int J Infect Dis. 2016 July; 48:49-51. PMID 27173076.
  24. Hilton S, Castro Nallar E, Pérez-Losada M, Toma I, McCaffrey T, Hoffman E, Siegel M, Simon G, Johnson W, Crandall K. Metataxonomic and Metagenomic Approaches Versus Culture-Based Techniques For Clinical Pathology. Front Microbiol. 2016 Apr 7;7:484. PMID: 27092134.
  25. Siegel M, Borkowska A, Roberts A, Parenti D, Dubrovsky L, Simmens S, Sviridov D, Simon G, Fitzgerald M, Bukrinsky M. HIV infection induces structural and functional changes in High Density Lipoproteins. Atherosclerosis 2015 Nov; 243: 19-29. PMID: 26343868.
  26. Swierzbinski M, Pandya S , Zelazny A, Keiser J, Siegel M. Diagnostic Challenges in the Identification of Rothia aeria Bacteremia in a Patient with Relapsing Acute Myeloid Leukemia.  Infectious Diseases in Clinical Practice 2015;23: 336–338
  27. Toma I, Siegel M, Keiser J, Yakovleva A, Kim A, Davenport L, Devaney J, Hoffman E, Alsubail R, Crandall K, Castro-Nallar E, Perez-Losada M, Hilton S, Chawla L, McCaffrey T, Simon G. Single-Molecule Long Read 16S Sequencing to Characterize the Lung Microbiome from Mechanically Ventilated Patients with Suspected Pneumonia. J Clin Microbiol. 2014 Nov;52(11):3913-21. PMID:25143582.
  28. Byrd A, Perez-Rogers J, Manimaran S, Castro-Nallar E, Toma I, McCaffrey T, Siegel M, Benson G, Crandall K, Johnson W. Clinical PathoScope: Rapid alignment and filtration for accurate pathogen identification in clinical samples using unassembled sequencing data. BMC Bioinformatics. 2014 Aug 4;15(1):262. PMID:25091138.
  29. Siegel M, Simon G. Is Human Immunodeficiency Virus Infection a Risk Factor for Strongyloides stercoralis Hyperinfection and Dissemination? PLoS Negl Trop Dis 2012;6(7): e1581. PMID: 22860137.
  30. Tiparneni N, Siegel M. Pulmonary and Peritoneal Tuberculosis Associated with Tumor Necrosis Factor-Alpha Inhibitor Use: A Case Report and Review of the Literature. Case Reports in Pulmonology, 2012, Article ID 598634, 4 pages, 2012. PMID:23304607
  31. Siegel M, Parenti D, Simon G. Atrial-Esophageal Fistula after Atrial Radiofrequency Catheter Ablation. Clin Infect Dis. 2010 Jul 1;51(1):73-6. PMID: 20482332.
  32. Siegel M, Kennedy L, Rexroth K, Lankford M, Turner M, McKnight A, Cummins S, Benator D, Kan V. Better But Not Ideal Acceptance of Routine Inpatient HIV Point-of-Care Testing among Veterans in a High Prevalence Area. J Acquir Immune Defic Syndr. 2010 May 20. PMID: 20502345.
  33. Siegel M, Fedorko D, Drake S, Calhoun L, Holland S. A Challenging Diagnosis: Legionella feeleii Serotype 2 Pneumonia in a Man with Chronic Lymphocytic Leukemia. J Clin Microbiol. 2010 Mar 31. PMID: 20357216.
  34. Siegel M, Timpone J. Penicillin-resistant Streptococcus pneumoniae endocarditis: case report and review. Clin Infect Dis. 2001 Mar 15;32 (6):972-4. PMID: 11247720.

Division

  • Infectious Diseases

Publications

Makhoul J, Uppal S, Siegel M. Double Trouble: Concomitant Unmasking and Paradoxical Immune Reconstitution Inflammatory Syndrome in a Patient with Newly Diagnosed HIV. IDCases. 2022 Mar 25

Sjaarda A, Bernstein A, Sparks A, Saber S, Siegel M. Comparison of Weight Gain after Antiretroviral Switch to Integrase Strand Transfer Inhibitor or Tenofovir Alafenamide-Based Therapy. Infection. 2022 Apr;50(2):407-412.

Corey L, Gilbert PB, Juraska M, et al; HVTN 704/HPTN 085 and HVTN 703/HPTN 081 Study Teams. Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition. N Engl J Med. 2021 Mar 18;384(11):1003-1014.

Baden LR, El Sahly HM, Essink B, et al, COVE Study Group. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021 Feb 4;384(5):403-416.

Harold R, Roberts A, Siegel M, Akselrod H, Simon G. Diagnostic dilemma: Ureaplasma septic polyarthritis in a 23-year-old female with Neuromyelitis optica receiving rituximab. BMJ Case Rep. 2021 Feb 1;14(2):e237916.

Weinreich DM, Sivapalasingam S, Norton T, et al, Trial Investigators. REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N Engl J Med. 2021 Jan 21;384(3):238-251.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None