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	Edward Seto Associate Center Director for Basic Sciences, GW Cancer Center King Fahd Professor of Cancer Biology Professor of Biochemistry and Molecular Medicine Office Phone: 202-994-3156 Email: Email Department: Biochemistry and Molecular Medicine

Education

• B.S., University of California, Irvine, 1981
• Ph.D., University of California, San Francisco, 1990

Biography

Dr. Seto’s laboratory focuses on understanding histone deacetylase, an enzyme that epigenetically regulates how certain genes turn on or off. As the associate center director, Dr. Seto is also developing three basic science research programs that will help the center’s bid for National Cancer Institute designation: cancer biology, immunology/immunotherapy, and microbial oncology.

Research

The Seto lab is devoted to obtaining a complete understanding of the functions, mechanisms of action, and regulation of histone deacteylases (HDACs), an enzyme that catalyze the removal of acetyl groups from the lysine residues of histones. These enzymes play a pivotal role in the regulation of gene transcription and are indispensable in numerous eukaryotic biological processes involving chromatin.

Visit Dr. Seto Lab Website

Grants

NIH R01 CA240529
Regulation of anti-tumor immunity by HDAC11
06/01/2020 – 05/31/2025

NIH T32 CA247756
Cancer Biology Training Program (CBTP)
07/01/2020 – 06/30/2025

NIH R01 AI153110
Design and development of HDAC11-specific chemical inhibitors for disease treatments
03/01/2021 – 02/28/2026

Awards

King Fahd Professor of Cancer Biology
 

Teaching

BMSC 8210
Genes to Cells

CANC 8221
The Basic Science of Oncology

CANC 8222
Molecular Oncology and Cancer Epigenetics

BIOC 6222
Biochemical Genetics and Medicine

BIOC 6230
New Technologies in Scientific Research

Centers and Institutes

GW Cancer Center

Programs

• GW Cancer Center

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

• None