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Edward Seto Edward Seto
Associate Center Director for Basic Sciences, GW Cancer Center
King Fahd Professor of Cancer Biology
Professor of Biochemistry and Molecular Medicine

Office Phone: 202-994-3156
Email: Email
Department: Biochemistry and Molecular Medicine


  • B.S., University of California, Irvine, 1981
  • Ph.D., University of California, San Francisco, 1990


Dr. Seto’s laboratory focuses on understanding histone deacetylase, an enzyme that epigenetically regulates how certain genes turn on or off.
His team is developing drugs and chemicals to manipulate the enzyme when it is expressing abnormally high levels in cancer. As the associate center director, Dr. Seto is also developing three basic science research programs that will help the center’s bid for National Cancer Institute designation: cancer biology, immunology/immunotherapy, and microbial oncology.


NIH R01 CA240529
Regulation of anti-tumor immunity by HDAC11
06/01/2020 – 05/31/2025

NIH T32 CA247756
Cancer Biology Training Program (CBTP)
07/01/2020 – 06/30/2025

NIH R01 CA187040
Targeting SIRT1 in Mantle Cell Lymphoma
7/3/2014 - 6/30/2021


King Fahd Professor of Cancer Biology


BMSC 8210
Genes to Cells

CANC 8221
The Basic Science of Oncology

CANC 8222
Molecular Oncology and Cancer Epigenetics

BIOC 6222
Biochemical Genetics and Medicine



The Seto lab is devoted to obtaining a complete understanding of the functions, mechanisms of action, and regulation of histone deacteylases (HDACs), an enzyme that catalyze the removal of acetyl groups from the lysine residues of histones. These enzymes play a pivotal role in the regulation of gene transcription and are indispensable in numerous eukaryotic biological processes involving chromatin.

Centers and Institutes

GW Cancer Center


  • GW Cancer Center


View publications by this faculty member.

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

  • None