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Bert B. Brooks Chair in the Medical School
Professor of Medicine
Office Phone: 202-741-2233
- B.Sc, St. Hindu College, 1977
- MBBS, Madurai Med Coll, 1982
- MD, Stanley Med Coll, 1988
Dominic Raj, MBBS, MD, DM, DNB, FACP, FASN is the Director of the Division of Kidney Diseases and Hypertension at the George Washington University School of Medicine. He is a Professor of Medicine, Biochemistry & Genetics and Biostatistics and Epidemiology at the GW.
Dr. Raj received his MBBS from the Madurai Medical College, residency in Internal Medicine at the Louisiana State University, Shreveport and a fellowship in nephrology at the University of Toronto. He is an invited Fellow of the American College of Physicians and a Fellow of the American Society of Nephrology. He was named “Innovator in Nephrology” by the American Association of Kidney Patients and recipient of the Peter Lundin Award, one of the highest honors presented to physicians for their significant contributions to the care and wellbeing of patients.
As a researcher, Dr. Raj is devoted to translating scientific discoveries from the laboratory to clinical practice. He is molecular epidemiologist, with specific interest in epigenetics. He is one of the principal investigators in the “Novel therapies in hemodialysis consortium” and the “Pilot Studies in CKD consortium” exploring new therapies for patients with kidney disease under the direction of the National Institute of Health. He is involved in several pivotal studies such as the Systolic Blood Pressure Intervention Trial (SPRINT), Canadian-Australasian Randomized Trial Of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK), Cardiac Arrhythmia Monitoring and Related Outcomes in End Stage Renal Disease Patients (CAMRO-ESRD) and APOL1 Long term kidney transplantation outcome Network (APOLLO). During his tenure, he established several international research collaborations and founded the “Mid-Atlantic Kidney Research Consortium” to advance kidney research. He is the recipient of the Distinguished Researcher Award from GW in 2014.
Dr. Raj is an opinion leader in nephrology and has more than 160 peer reviewed publications. He has been invited to speak, organize and chair more than 100 scientific sessions across the world. He has been a visiting professor to more than 30 institutions across the world including Radboud Institute for Molecular Life Sciences, Harvard Medical School, Cornell University, Michigan University and New York University. He has served as a grant reviewer for the National Institute of Health, the European Union, the French Research Agency, the Canadian Center for Innovation and the Welcome Trust.
Dr. Raj is an excellent clinician with specific interest in diabetic nephropathy and complicated hypertension. He has been named Washington Top Doctor multiple times. He established several sub-specialty clinics and expanded the clinical service to Maryland and Virginia. He is pivotal to establishing the kidney transplant program and expansion of extracorporeal therapies at GW. During his tenure at the GW, the Division was recognized as “High Performing” US News and World Report.
- Chronic Kidney Disease
- Adult Polycystic Kidney Disease
- Cardiorenal syndrome
- Diabetic Kidney Disease
- Cardiorenal Syndrome
- Novel Dialysis Therapies
- MBBS- Madurai Medical College, India
- MD- Stanley Medical College, India
- DM- Nephrology, Christian Medical College, India
- DNB- Nephrology, Christian Medical College, India
- Internal Medicine Residency- Louisiana State University, Shreveport, LA
- Fellowship in Nephrology- University of Toronto, Canada
- The division has expanded the research portfolio by promoting lab-based research and establishing a Clinical Trial Unit within the Division
- Established research collaboration with AstraZeneca research division to conduct basic science and phase II studies
- Partnered with NIH intramural to conduct translational research
- Recruited basic science researchers into the division (first clinical division at GWU to do it)
- Our faculty members have research collaborations with nationally and internationally acclaimed investigators and also have assisted students and young nephrologists from GWU.
- We established the Mid-Atlantic Kidney Research Consortium formed by GWU, Georgetown University, Howard University, University of Virginia, Inova Health Care system, University of Maryland and Johns Hopkins University to foster collaborative research. Originally conceived for the Precision Medicine Project, it has yielded two projects “CAMARO study” and “APOLLO study”
- Last year the faculty members published 55 manuscripts in peer reviewed journals and 30 abstracts in national meetings. Annual research funding for the division is about 3.3 million dollars at present and we expect it to increase it by 2018.
- Urine single cell transcriptomics to characterize podocyte disease. GW Office of Research and NIH Intramural. PI Regunathan
- Uremic Toxin Depletion by Methanogenic Archaea. Young Investigator Award from NKF. PI Ali Ramezani
- Renal G Protein-Coupled Receptor 37L1 Regulates Blood Pressure. NIH R56DK116828, PI: Prasad Konkalmatt
- A peripheral dopamine ? hydroxylase inhibitor and treatment of pulmonary arterial hypertension. PI, BIAL, Inc, Porto, Portugal, 2019-202; PI: Pedro A. Jose
- G-protein coupled receptor kinase 4 inhibitor, National International Cooperation Base for Cardiovascular Diseases” Collaborator, PI, Chunyu Zeng, Third Military Medical University, Chongqing, China, 2017-2019, Collaborator: Pedro A. Jose
- Renal Dopamine-1 Receptor Defect in Hypertension, 5R01 DK039308, 1991-2020, PI: Pedro A. Jose
- Animal Models of Salt Sensitivity: Roles of GRK4 and Sodium Transporters on Salt Sensitivity, 5P01 HL074940, 2004-2021, PI Pedro A. Jose, Director, Project 3,
- Calcium transport in kidney proximal tubule and calcium phosphate stone formation, 1R01 DK102043, 2015-2020, Consultant- Pedro A. Jose
- Anti-inflammatory therapy in diabetic CKD. NIH U01DK099914. PI Dominic Raj
- Gut microbiota and atherosclerosis in ESRD. NIH U01DK099924. PI Dominic Raj
- SPRINT-Electronic Health Record (SPRINT-EHR). NIH R011HL136679-01A1- Site-PI: Dominic Raj Site PI
- Cardiac Arrhythmia Monitoring and Related Outcomes in Hemodialysis (CAMARO HD). R01HL132372. Site-PI Dominic Raj
- The effects of Patiromer on serum potassium level and gut microbiome of ESRD patients with hyperkalemia. Investigator Initiated Study funded by Relypsa. PI Dominic Raj
- IL-6 pathway genes associated renal, cardiovascular and hematological phenotypes in CKD: Findings from the CRIC study. I Investigator Initiated Study, funded by Carvedia. PI Dominic Raj
- Profiling microbiome in CKD. Investigator Initiated Study funded by Kaleido. PI Dominic Raj
- An observational study to investigate the immunopathophysiology of diabetic kidney disease. Co-developed and funded by Medimmune. PI Dominic Raj
- MicroRNA and progression of atherosclerosis. GW Office of Research. PI Dominic Raj
- APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) (APOLLO). NIH PI. Jagadeesan/Raj
- Member of the Clinical Integrative Cardiovascular study section
- Board of Directors of the National Kidney Foundation
- Renal Diseases and Hypertension
Poesen R, PhD, Ramezani A, Claes K, Augustijns P, Kuypers D, Barrows IR, Muralidharan J, Evenepoel P,Meijers B, Raj DS. Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with chronic kidney disease. C J Am Soc Nephrol (In press)
Poesen R, PhD, Ramezani A, Claes K, Augustijns P, Kuypers D, Barrows IR, Muralidharan J, Evenepoel P,Meijers B, Raj DS. Associations of soluble CD14 and endotoxin with mortality, cardiovascular disease, and progression of kidney disease among patients with chronic kidney disease. C J Am Soc Nephrol (In press)
Paul R, Raj DS. Metabolic Synergy to Uremic Toxicity: A Tale of Symbiosis and Dysbiosis in CKD. NephSap Editorial (In press)
Bansal N, Zelnick L, Bhat Z, Dobre M, He J, Lash J, Jaar B, Mehta R, Raj DS, Rincon-Choles H, Saunders M, Schrauben S, Weir M, Wright J, Go A. Burden and outcomes associated with heart failure hospitalizations in adults with CKD: the CRIC Study, J Am Col Cardiol (In press)
Expanding Medicare Coverage to Include Lifetime Immunosuppression Drugs for Renal Transplant Recipients. Center for Health Policy and Media Engagement of George Washington University School of Nursing
Montgomery LD, Montgomery RW, Gerth WA, Lew SQ, Velasquez MT, Stewart JM, Medow MS, Klein MM. Monitoring intracellular (Vc), interstitial (Vi) and intravascular (Vb) volume changes during dialysis (HD) in a chronic unit (CU) compared to an acute unit (AU) setting. J Nephrol Kidney Dis. 2019;3(1): 1019
Ix JH, Isakova T, Larive B, Raphael KL, Raj DS, Cheung AK, Sprague SM, Fried L, Gassman JJ, Middleton J, Flessner M, Block G, Wolf M. Effects of Nicotinamide and Lanthanum Carbonate on Serum Phosphate and Fibroblast Growth Factor-23 in Chronic Kidney Disease: The COMBINE Trial. J Am Soc Nephrol 2019; In Press.
Regunathan-Shenk R, Avasare RS, Ahn W, Canetta PA, Cohen DJ, Appel GB, Bomback AS. Kidney Transplantation in C3 Glomerulopathy: A Case Series. Am J Kidney Dis. 2019;73:316-323.
CureGN Consortium including Renu Regunathan-shenk. CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.. Am J Kidney Dis. 2019;73:218-229.
Zheng X, Asico LD, Ma X, Konkalmatt PR. G protein-coupled receptor 37L1 regulates renal sodium transport and blood pressure. Am J Physiol Renal Physiol. 2019 Mar 1;316(3):F506-F516.
Li P, Nader M, Lessey, G, and Papademetriou V. Device-Based Therapy for Treatment -Resistant Hypertension: Recent updates. EC Cardiology 6(5):429-443; 2019
Bayoumi E, Lam PH, Dooley DJ, Singh S, Faselis C, Morgan CJ, Patel S, Sheriff HM, Mohammed SF, Palant CE, Pitt B, Fonarow GC, Ahmed A. Spironolactone and Outcomes in Older Patients with Heart Failure and Reduced Ejection Fraction. Am J Med. 2019;132:71-80.
Amosco MD, Tavera GR, Villar VAM, Naniong JMA, David-Bustamente LMG, Williams SM, Jose PA, Palmes-Saloma CP. Non-additive effects of ACVR2A in preeclampsia, in a Philippine population. BMC Pregnancy Childbirth. 2019; 19:11. PMC6323705
Wang S, Tan X, Chen P, Zheng S, Ren H, Cai J, Zhou L, Jose PA, Yang J, Zeng C. Role of thioredoxin 1 in impaired sodium excretion of hD5RF173L transgenic mice. J Am Heart Assoc J Am Heart Assoc. 2019; 8(8):e012192.
Rao X, Asico LD, Zanos P, Mahabeleshwar GH, Singh Gangwar R, Xia C, Duan L, Cisse YM, Rengasamy P, Jose PA, Gould TD, Nelson R, Biswal S, Chen LC, Zhong J, Rajagopalan S. Alpha2B-Adrenergic Receptor Overexpression in the Brain Potentiate Air Pollution-induced Behavior and Blood Pressure Changes. Toxicol Sci. 2019 Jan 25. pii: kfz025.
Ibeh CL, Yiu AJ, Kanaras YL, Paal E, Birnbaumer L, Jose PA, Bandyopadhyay BC. Evidence for a regulated Ca2+ entry in proximal tubular cells and its implication in calcium stone formation. J Cell Sci. 2019 Mar 25. pii: jcs.225268.
Yang J, Villar VM, Rozyyev S, Jose PA. The emerging role of sorting nexins in cardiovascular diseases. SClin Sci (Lond). 2019; 133:723-737
Cuevas S, Villar VAM, Jose PA. Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation. Pharmacogenomics J. 2019 Feb 6. doi: 10.1038/s41397-019-0082-4.
Mehrotra R, Cukor D, Unruh M, Rue T, Heagerty P, Cohen SD, Dember LM, Diaz-Linhart Y, Dubovsky A, Greene T, Grote N, Kutner N, Trivedi MH, Quinn DK, Ver Halen N, Weisbord SD, Young BA, Kimmel PL, Hedayati SS. Comparative efficacy of therapies for treatment of depression for patients undergoing maintenance hemodialysis: a randomized clinical trial. Ann Intern Med. 2019 Feb 26. [Epub ahead of print]
Lew SQ, Sikka N. Operationalizing telehealth for home dialysis patients in the United States. Am J Kidney Dis. 2019 Mar 18[Epub ahead of print]
Shah NB, Allegretti AS, Nigwekar SU, Kalim S, Zhao S, Lelouvier B, Servant F, Serena G, Thadhani RI, Raj DS, Fasano A. Blood Microbiome Profile in Chronic Kidney Disease: A Pilot study. C J Am Soc Nephrol. 2019, 4, :692-701.
Barrows IR, Ramezani A, Raj DS. Inflammation, Immunity and Oxidative Stress in Hypertension- Partners in Crime? Adv CKD. 2019, 26:122-130.
Amdur RL, Feldman HI, Dominic EA, Anderson AH, Beddhu S, Rahman M, Wolf M, Reilly M, Ojo A, Townsend RR, Go AS, He J, Xie D, Thompson S, Budoff M, Kasner S, Kimmel PL, Kusek JW, Raj DS. Use of inflammation and measures of kidney function combined with pooled cohort equation risk estimates in prediction of atherosclerotic vascular disease Events and death for patients with CKD. Am J Kidney Dis. 2019, 73, 344-353
Charytan DA, Himmelfarb J, Ikizler TA, Raj DS, Hsu JY, Landis JR, Anderson AH, Hung AM, Mehrotra R, Sharma S, Weiner DE, Williams M, DiCarli M, Skali H, Kimmel PL, Kliger AS, Dember LM. For the Hemodialysis Novel Therapies Consortium. Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD (SPin-D): A Randomized, Placebo-Controlled, Multiple Dosage Trial. Kidney Int. 2019;95: 973-982
Villar VA, Asico LD, Wang X, Konkalmatt P, Yang J, Gomes J, Rozyyev S, Tiu AC, Cuevas S, Armando I, Jose PA. Salt Sensing & Salt Response of Renal Neuropeptide FF Receptor 2. Abstract D182 - 569.12, EB Meeting April 7, 2019, Orlando, FL.
Rozyyev S, Konkalmatt P, Villar VA, Asico LD, Kumar M, Hunt J, Jose PA, Armando I. Molecular mechanisms underlying the GRK4 65L-mediated hypertension in mice. Abstract E706 - 597.2, EB Meeting April 7, 2019, Orlando, FL.
Zhu G, Yu GT, Ren S, Asico LD, Jose PA, Wang X. The salt-sensitivity in C57Bl/6J mice is linked to increased renal protein expressions of SLC4A4 and SLC4A5.C344 - 533.11, EB Meeting April 7, 2019, Orlando, FL.
Asico LD, Hunt J, Wang X, Armando I, Wank SA, Yagnesh TH. Wang TC, Raj D, Jose PA. Minocycline Normalizes the Hypertension in Gastrin-/- Mice. Abstract C563 - 724.6 EB Meeting April 8, 2019, Orlando, FL.
Konkalmatt PR, Asico LD, Villar VA, Cuevas S, Armando I, and Jose PA. Gastrin Enhances the Sodium induced GLP-1 secretion in the L-Cells. Abstract C295 - 692.4EB Meeting April 8, 2019, Orlando, FL.
Zheng X, Asico LD, Armando I, Jose PA, and Konkalmatt PR. GPR37L1 Regulates the Expression and Function of NHE3 in Renal Proximal Tubule Cells. Abstract C295 -692.4EB Meeting April 9, 2019, Orlando, FL.
Kumar M, Konkalmatt P, Asico LD, Hunt J, Latham PS, Jose PA and Armando I. Differential Effects of Specific Deletion of the Dopamine D2 Receptor in Renal Proximal Tubules of Male and Female Mice. Abstract D60 - 864.10, EB Meeting April 9, 2019, Orlando, FL.
Rozyyev S, Crusan AP, Tiu AC, Jurgens JA, Quion JMB, Asico LD, Felder RA, Jose PA, and Villar VA. Tandem Requirement for Renal D1R and D5R Functionality. Abstract D16 – 862.18, EB Meeting April 9, 2019, Orlando, FL.
J.K.Melancon,K.Mahendran, M.Jagadeesan,R.Ranga,N.Koizumi. . Bortezimab based induction decreases delayed graft function in high risk kidney transplantation. Oral Presentation at the American Transplant Congress, Boston, June 2019
Nader MA, Campos RA, Hassan O, Cervantes CE, Correa R, Sharma P, Shafique R, Vo HQ, Hamze O, Gordon J, and Li P. The Impact of Debility on Inpatient Mortality and Hospital costs of ESRD patients in the Unites State: a nationwide Study. TH-PO280, ASN 2018.
Lisa Prince, Brian Y’Barbo, Jeffrey Mikita, Anna Howle, Scott Cohen, Oliver Lenz, Laura Maursetter, Sharon Maynard, Stephen Sozio, Amy Sussman, Christina Yuan Breaking Bad News: A 2 Year, Multi-Center Simulation Exercise Assessing Renal Replacement Therapy and Kidney Biopsy Communication Skills. American Society of Nephrology Renal Week 2018, San Diego
Haile H, Kumar M, Armando I, Jose, PA. Differential histone deacetylase expression in human renal proximal tubule cells carrying GRK4 65?L and SLC4A5 variants. STEP-UP Undergraduate Summer Research Symposium, NIDDK, Jul 29-August 2, 2018, 2018 Annual Biomedical Research Conference for Minority Students (ABRCMS), Nov 14-17, 2018, Indianapolis, IN.
Wang X, Ma C, Asico LD, Jose PA. Increased renal protein expressions of SLC4A4 and SLC4A5 in salt-sensitive C57Bl/6J mice, 2018 Kidney Week. Abstract PO323. 2018 Kidney Week, San Diego, CA.
Ramezani A, Nolin T, Barrows I, Serrano MG, Buck G, West RE III, Latham PS, Amdur R, Raj DS. Effect of Gut Colonization with Methanogenic Archaea on Plasma TMAO Concentrations and Atherosclerosis in Apolipoprotein e-/- Mice. Nature Scientific Reports, volume 8, Article number: 14752 (2018)
Supiano MA, Lovato L, Ambrosius WT, Bates J, Beddhu S, Drawz P, Dwyer JP, Hamburg NM, Kitzman D, Lash J, Lustigova E, Miracle CM, Oparil S, Raj DS, Weiner DE, Taylor A, Vita JA, Yunis R, Chertow GM, Chonchol M. Pulse wave velocity and central aortic pressure in systolic blood pressure intervention trial participants. PLoS One. 2018 Sep 26;13(9):e0203305. doi: 10.1371/journal.pone.0203305. eCollection 2018.
Lew SQ. Telehealth in peritoneal dialysis: Review of patient management. Adv Perit Dial 2018;34:32-37.
Lew SQ, Sikka N, Thompson C, Magnus M. Impact of remote biometric monitoring on cost and hospitalization outcomes in peritoneal dialysis. J Telemed Telecare 2018 Jan 1 epub ahead of print
Wu G, Jose PA, Zeng C. Noncoding RNAs in the regulatory network of hypertension. Hypertension. 2018; 72(5):1047-1059
Wang J, Deng Y, Zou X, Luo H, Jose PA, Fu C, Yang J, Zeng C. Long-term low salt diet increases blood pressure by activation of the renin-angiotensin and sympathetic nervous systems. Clin Exp Hypertens. 2018;18:1-8.
CureGN Consortium including Renu Regunathan-shenk. Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study. Kidney Int Rep. 2018;3:1373-1384.
Palant CE, Patel SS, Chawla LS. Acute Kidney Injury Recovery. Contrib Nephrol. 2018;193:35-44.
Armando I, Jose PA. Soares-da-Silva P. Antihypertensive effect of etamicastat in dopamine D2 receptor deficient mice. Hypertens Res. 41(7):489-498, 2018.
Yang X, Yue R, Zhang J, Zhang X, Liu Y, Chen C, Wang X, Luo H, Wang WE, Chen X, Wang HJ, Jose PA, Wang H, Zeng. Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways. J Am Heart Assoc. 7(14). pii: e005171, 2018.
Jiang X, Liu J, Xing, Liu X, Wang W, Wang Z, Hu Y, Zhang Y, Zhang Y, Jose PA, Wei Q, Yang Z. Over-expression of a cardiac-specific human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 degradation. Redox Biol. 2018;19:134-146.
Luo H, Chen CY, Guo L, Xu ZC, Peng XY, Wang XQ, Wang JL, Wang N, Li CW, Luo XL, Wang HY, Jose PA, Fu CJ, Huang Y, Shi WB, Zeng CY. Exposure to maternal diabetes mellitus causes renal dopamine D-1 receptor dysfunction and hypertension in adult rat offspring. Hypertension. 2018; 72;962-970
Babar F, Cohen SD. Thrombotic microangiopathies with rheumatologic involvement. Rheum Dis Clin North Am 2018; 44: 635-649
Cohen SD, Kimmel PL. Management of nonadherence in ESKD patients. Clin J Am Soc Nephrol 2018; 13: 1080-1082
Lew SQ. Peritoneal dialysis immediately after abdominal surgery. Perit Dial Int 2018;38:5-8.
Lew SQ, Sikka N. Telehealth and peritoneal dialysis in the US: outcomes in practice. J Kidney Care 2018;3(3):156-160.
Emami S, Lew SQ. Candida glabrata PD-associated peritonitis: A case report. Perit Dial Int 2018;38(5): 391-392.
Lew SQ. Maintaining peritoneal dialysis adequacy: The process of incremental prescription. Adv Perit Dial 2018;34:10-14.
Qiu C, Hanson RL, Fufaa C, Kobes S, Gluck C, Huang J, Chen Y, Raj DS, Nelson RG, Knowler WC, Susztak K. Cytosine methylation predicts renal function decline in American Indians. Kidney Int. 2018;93:1417-1431.
Prasad PV, Wei Li, Raj DS, Carr J, Carr M, Thacker J, Lu-Ping Li, Chi Wang, Sprague SM, Ix JH, Chonchol M, Block G, Cheung AK, Raphael K, Gassman J, Wolf M, Fried LF, Isakova T, CKD Optimal Management with BInders and NicotinamidE (COMBINE) Study Group. Multi-center Study Evaluating Intra-renal Oxygenation and Fibrosis using MRI in Individuals with Advanced CKD. Kidney Int Reports DOI: https://doi.org/10.1016/j.ekir.2018.07.006
Velasquez MT, Centron P, Barrows I, Dwivedi R, Raj DS. Gut Microbiota and Cardiovascular Uremic Toxicities. Toxin, 2018 http://www.mdpi.com/2072-6651/10/7/287
Yang S, Ambrosius WT, Fine LJ, Bress AP, Cushman WC, Raj DS, Rehman S, Tamariz L. A New Modeling and Inference Approach for the SPRINT Trial Outcomes. Journal of the Society for Clinical Trials 2018 Jun;15(3):305-312.
Roumelioti ME, Glew RH, Khitan ZJ, Rondon-Berrios H, Argyropoulos CP, Malhotra D, Raj DS, Agaba EI, Rohrscheib M, Murata GH, Shapiro JI, Tzamaloukas AH: Fluid balance concepts in medicine: Principles and practice. World J Nephrol 7:1-28, 2018
Chung A and Li P, IV iron Therapy Induced Acute Hypophosphatemia in CKD patients. FR-PO602, ASN 2018.
Raphael KL, Isakova T, Ix JH, Raj DS, wolf M, Fried LF, Gassman JJ, Larive B, Abbott, KC, Mendley SR, Block GA, Li P, Middleton JP, Sprague SM, Wesson DE, Cheung AK. CKD Polit studies consortium. A Multicenter, Randomized Pilot Study of oral Sodium Bicarbonate Supplementation in non- to mildly Acidotic CKD: BASE Pilot Study. SA-OR036, ASN, 2018.
Nader MA, Campos RA, Hassan O, Cervantes CE, Correa R, Sharma P, Shafique R, Hamze O, Vo HQ, Gordon J, Li P. The Impact of gender on inpatient mortality of hypertensive Latino patients across CKD stage 3 to ESRD in the United States. TH-PO1045, ASN 2018.
Tiu AC, Asico LD, Konkalmatt P, Zheng X, Cuevas S, Wang X, Mazhar M, Jose PA, Villar AM. Sorting nexin 19: A novel and key player in renal dopamine D1R regulation. Abstract 047. Oral presentation 2018 AHA Council on Hypertension. Judged to be among the top 10 percent of the accepted abstracts presented at the AHA Council on Hypertension. Invited to be a poster presentation at the 2018 AHA Scientific Sessions in a Session titled “Best AHA Specialty Conferences: Hypertension 2018. Tiu AC received the Young Investigator Award, Chicago, IL.
Nader MA, Campos RA, Hassan O, Cervantes CE, Correa R, Sharma P, Shafique R, Vo HQ, Hamze O, Li P, and Gordon J. The Impact of Gender in inpatient mortality of hypertensive patients with CKD 3 to ESRD in the US. TH=PO 1106, ASN 2018.
Kumar M, Asico L, Konkalmatt P, Freyberg Z, Jose PA, Armando I. Role of dopamine D2 receptors in the regulation of cell proliferation in renal injury. Abstract 052. Oral presentation 2018 AHA Council on Hypertension, Chicago, IL.
De Miguel C, Saludes M, Asico LD, Latham PS, Offen D, Jose PA, Cuevas S. ND-13, a DJ-1-derived peptide, protects against the renal fibrosis and inflammation associated with unilateral ureter obstruction. Abstract 055. Oral presentation 2018 AHA Council on Hypertension, Chicago, IL.
Cuevas S, Asico LD, Jose PA, Konkalmatt P. Renal hydrogen peroxide prevents salt-sensitive hypertension. Abstract 062. Oral presentation 2018 AHA Council on Hypertension, Chicago, IL.
Asico LD, Villar VM, Bishop M, Gomes G, Mazhar M, Jose PA. NPFF receptors NPFF-R1 and NPFF-R2 in the kidney: A target for the negative control of sodium transport and blood pressure. Abstract 087. Oral presentation 2018 AHA Council on Hypertension, Chicago, IL.
Zheng X, Konkalmatt P, Asico L, Jose PA, Armando I. Salt resistance and renal Gpr83 function. Abstract 093. Oral presentation 2018 AHA Council on Hypertension, Chicago, IL.
Rozyyev S, Konkalmatt P, Asico L, Kumar M, Hunt J, Jose PA, Armando I. Rena-specific expression of human GRK4 R65L in mice lacking Grk4 increases blood pressure. Abstract 115. Oral presentation 2018 AHA Council on Hypertension, Chicago, IL.
Daley MG, Gildea JJ, Xu P, Schiermeyer KA, Yue W, Marshall SG, Jose PA, Felder RA. Development of an automated high throughput screen for GRK4 as potential novel therapeutics for treatment of hypertension and/or salt sensitivity. Abstract P256. Poster presentation 2018 AHA Council on Hypertension, Chicago, IL.
Xu P, Gildea JJ, Yue W, Jose PA, Felder RA. Renal proximal tubule cells from inverse salt sensitive individuals have lower basal but higher sodium stimulated ENaC compared to salt resistant individuals. Abstract P263. Poster presentation 2018 AHA Council on Hypertension, Chicago, IL.
Rajnish Mehrotra, Daniel Cukor, Mark L Unruh, Tessa Rue, Patrick J Heagerty, Scott D Cohen, Laura Dember, Yaminette Diaz-Linhart, Amelia Dubovsky, Tom Greene, Nancy K Grote, Nancy G Kutner, Madhukar Trivedi, Davin Quinn, Nisha ver Halen, Steven D. Weisbord, Bessie A. Young, Paul L. Kimmel, S, Susan Hedayati. Comparative Efficacy of Therapies for Depression for Patients Undergoing Hemodialysis: A Trial of Sertraline vs. CBT for End Stage Renal Disease Patients with Depression (ASCEND). American Society of Nephrology Renal Week 2018, San Diego, Abstract selected for Late Breaking Clinical Trials Oral Session
J.K.Melancon,K.Mahendran, M.Jagadeesan,R.Ranga,N.Koizumi. ABO incompatible deceased donor kidney transplantation –Time to remove the barrier American Society Of Transplant Surgeons – Winter Symposium,2018.
J.K.Melancon,K.Mahendran, M.Jagadeesan,R.Ranga,N.Koizumi. ABO incompatible deceased donor kidney transplantation –Time to remove the barrier. American Transplant Congress, Annual meeting 2018. Society of Black Academic Surgeons
J.K.Melancon,K.Mahendran, M.Jagadeesan,R.Ranga,N.Koizumi. . Bortezimab based induction decreases delayed graft function in high risk kidney transplantation. . Society of Black Academic Surgeons,New York,2018 – Oral Presentation.
K.Mahendran, M.Jagadeesan,R.Ranga,N.Koizumi. ABO incompatible deceased donor kidney transplantation –Time to remove the barrier . Society of Black Academic Surgeons, Birmingham,Alabama,2018
J.K.Melancon,K.Mahendran, M.Jagadeesan,R.Ranga,N.Koizumi. Bortezimab based induction decreases delayed graft function in high risk kidney transplantation. American Society Of Transplant Surgeons – Winter Symposium,2018
Gupta J, Dominic EA, Fink JC, Ojo AO, Barrows IR, Reilly MP, Townsend RR, Joffe MM, Rosas SE, Wolman M, Patel SS, Keane MG, Feldman HI, Kusek JW, Raj DS. Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study. PLos one, 2015 (In press)
Wing MR, Devaney JM, Joffe MM, Raj DS. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC Study. Nephrol Dial Transplant 29:864-72, 2014.
Rambod, M, Heine GH, Seiler S, Dominic EA, Rogacev KS, Dwivedi RS, Ramezani A, Wing MR, Fliser D, Raj DS: Association of vascular endothelial factors with cardiovascular outcome and mortality in chronic kidney disease patients: A 4-year cohort study. Atherosclerosis. 236):360-365, 2014
Ramezani A, Raj DS: Gut microbiome, kidney disease and targeted interventions J Am Soc Nephrol 25:657-70. 2014
Parsa A, Kao WH, Xie D, Astor BC, Li M, Hsu CY, Feldman HI, Parekh RS, Kusek JW, Greene TH, Fink JC, Anderson AH, Choi MJ, Wright JT, Jr., Lash JP, Freedman BI, Ojo A, Winkler CA, Raj DS, Kopp JB, He J, Jensvold NG, Tao K, Lipkowitz MS, Appel LJ: APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease. N Engl J Med 369(23):2183-96, 2013
Gupta J, Mitra N, Kanetsky PA, Devaney J, Wing MR, Reilly M, Shah VO, Balakrishnan VS, Guzman NJ, Girndt M, Periera BG, Feldman HI, Kusek JW, Joffe MM, Raj DS: Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile. Clin J Am Soc Nephrol 7:1938-1946, 2012
Raj DSC, Carrero JJ, Shah VO, Barany P, Heimburger O, Ferguson J , Moseley PL, Stenvinkel P: Soluble CD14 level and protein energy wasting, inflammation complex in ESRD. Am J Kidney Dis; 54:1072-1080, 2009
Shah V, Scariano J, Waters D, Qualls C, Morgan M, Pickett G, Gasparovic C, Dokladny K, Moseley P, Raj DSC: Mitochondrial DNA deletions and sarcopenia. Genetics in Medicine 11, 147-152, 2009
Raj DSC, Moseley P, Dominic EA, Onime A, Tzamaloukas AT, Boyd A, Shah VO, Glew R, Wolfe R, Ferrando A: Interleukin-6 modulates Hepatic and muscle protein synthesis during hemodialysis. Kidney Int 73 1054-1061, 2008
Raj DS, Lim G, Levi M, Qualls C, Jain SK, Advanced glycation end products and oxidative stress are increased in chronic allograft nephropathy: Am J Kidney Dis 43, 154-160, 2004
Raj DS, B Vincent, K Simpson, Sato E, Jones KL, Welbourne TC, Levi M, Shah V, Blandon P, Zager P, Robbins R: Hemodynamic changes during hemodialysis: Role of nitric oxide and endothelin. Kidney Int, 61 (2), 697-704, 2002
Raj DS, Self M, Work J: Hybrid Dialysis; Recirculation peritoneal dialysis revisited. Am J Kidney Dis, 36 (1),58-67, 2000
Raj DS, Ouwendyk M, Francoeur R, Uldall R, Pierratos A: Beta2 Microglobulin kinetics in nocturnal hemodialysis. Nephrol Dial Transplant. 15, 58-64, 2000
Raj DS, Charra B, Pierratos A, Work J: In search of ideal hemodialysis: Is prolonged and frequent dialysis the answer? Am J Kidney Dis:34;1-14,1999
Raj DS, Roscoe J, Manuel MA, Abreo K, Dominic SS, Work J: Is peritoneal dialysis a good option in blacks? Am J Kidney Dis 33:325-333; 1999
Raj DS. On time and frequency of dialysis. Int J Artif Organs, 22; 1-7, 1999
Pierratos A, Ouwendyk M, Vas S, Francoeur R, Raj DSC, Ecclestone A, Logos V, Uldall R: Nocturnal hemodialysis: Three years experience. J Am Soc Nephrol 9:859-868, 1998
Raj DS, Tobe S, Saiphoo CS, Manuel MA: Mass balance index: An index for dialysis adequacy and nutrition. Int J Artif Organs 21:422-427,1998
Raj DS, Langos V, Gangam N, Roscoe J: Ethnic variability in peritoneal equilibration test and urea kinetics. Am J Kidney Dis 30:374-381, 1997
Raj DS, Tobe S, Saiphoo CS, Manuel MA: Quantitating dialysis using two dialysate samples: a simple, practical and accurate approach for evaluating urea kinetics. Int J Artif Organ 20:4271997
Raj DS, D'Mello S, Somiah S, Sheeba SD, Mani K: Left ventricular morphology and function in chronic renal failure. Renal Failure. 19:799-806, 1997
Bhaskaran S, Tobe S, Saiphoo CS, Moldoveanu A, Raj DS, Manuel MA: Blood urea levels 30 minutes before the end of dialysis are equivalent to equilibrated blood urea. ASAIO J 43:1997
Raj DS, Hoisala R, Somiah S, Sheeba SD, Yeong M: Quantitation of change in medullary compartment of renal allograft. J Clin Ultrasound 25:265-269, 1997
Raj DS, Ramachandran S, Somiah S, Mani K, Dominic SS: Quenching the thirst in dialysis patients. Nephron 73:597-600, 1996
Raj DS, Somiah S, Mani K, Sheeba SD, Shet A: Valvular dysfunction in uremia. Ind J Med Res 103:98-102, 1996
Raj DS, Somiah S, Mani K: Optimal cyclosporine therapy. JAPI 44:34-36, 1995
Raj DS, Somiah S, Mani K, Sheeba SD, Prabhu KN: Effect of diltiazem on cyclosporine profile. In J Nephrol 5:12-14, 1995
Raj DS, Somiah S, Srinivas, Sheeba SD, Swapna: Acute renal failure in disseminated intravascular coagulation. In J Nephrol 5:47-49, 1995
Raj DS, Usha K: Renal replacement by hemodialysis. Vol. 5, No.1; 1993. Physician Update 5:12-19, 1993
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.