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David Diemert David Diemert
Professor of Medicine
Professor of Microbiology, Immunology, and Tropical Medicine (Secondary)

Office Phone: 202-994-2909
Email: Email
Department: Medicine

Biography

Dr. David Diemert is a Professor in the Departments of Medicine (primary) and Microbiology, Immunology, and Tropical Medicine (secondary) at GW. Additionally, he is the Director of GW Vaccine Research Unit (GW VRU), which is a collaboration between the School of Medicine and Health Sciences, GW MFA, and the Milken Institute School of Public Health. At GW, Dr. Diemert is also the co-Director of the Immunohematology and Infection block of the preclinical medical student curriculum. Prior to joining GW, Dr. Diemert worked for four years at the Malaria Vaccine Development Branch of the National Institute of Allergy and Infectious Diseases, where he was responsible for conducting clinical trials of novel malaria vaccines in the United States and in Mali, West Africa. Dr. Diemert earned his medical degree from the University of Alberta in Edmonton, Canada, and completed residency and fellowship training at McGill University in Montreal. He is a Fellow of the Royal College of Physicians (Canada) with certification in the specialties of internal medicine, infectious diseases and medical microbiology. Additionally, he received training in clinical tropical medicine through the University of Alabama at Birmingham’s Gorgas Course in Lima, Peru.

Research

Dr. Diemert’s research is focused on conducting clinical trials to develop new vaccines for neglected tropical diseases and viral infections in the United States, Brazil, and Africa. He has served as the Principal Investigator on multiple clinical trials of COVID-19, influenza, respiratory syncytial virus (RSV), HIV, hookworm, schistosomiasis, Lassa fever, malaria, and flavivirus vaccines. More recently, he has developed controlled human infection models (“CHIMs”) at GW for intestinal helminths such as hookworm and whipworm (Trichuris trichiura) to test the efficacy of interventions such as investigational vaccines and medications as well as the immunomodulatory effect of these parasites on inflammatory diseases such as ulcerative colitis and Crohn’s Disease. He currently has funding from NIAID/NIH, US Department of Defense, the International AIDS Vaccine Initiative (IAVI), Pfizer, and Sanofi Pasteur.

Dr. Diemert’s international work has involved establishing clinical trial sites in resource limited settings such as one in the state of Minas Gerais, Brazil. This site has been established in partnership with the Fundação Oswaldo Cruz (FIOCRUZ), and has included establishing a clinic in a rural area of Brazil, assembling and training a Brazilian clinical trials team, establishing quality laboratory facilities at the field site, conducting preparatory studies of helminth epidemiology and immunology, and overseeing several Phase 1 and 2 trials of investigational vaccines for hookworm and schistosomiasis. Additional international partnerships with the Centre de Recherches Médicales de Lambaréné (CERMEL) in Gabon and the Makerere University Walter Reed Project (MUWRP) in Uganda have resulted in successful Phase 1 and 2 trials of investigational vaccines targeting neglected tropical diseases.

Publications

Scholte LLS, Leggat DJ, Cohen KW, Hoeweler L, Erwin GC, Rahaman F, Lombardo A, Philiponis V, Laufer DS, Siefers H, Ruppel AM, Brand J, Maenza J, Bronson R, Prabhakaran M, Jean-Baptiste J, Kolokythas O, Desrosiers AA, Thoreson CK, Heit A, Khati NJ, Malkin E, McElrath MJ, McDermott AB, Schief WR, Diemert D, Bethony JM. Ultrasound-guided lymph node fine-needle aspiration for evaluating post-vaccination germinal center responses in humans. STAR Protoc. 2023 Sep 20;4(4):102576.

Branche AR, Rouphael NG, Diemert DJ, Falsey AR, Losada C, Baden LR, Frey SE, Whitaker JA, Little SJ, Anderson EJ, Walter EB, Novak RM, Rupp R, Jackson LA, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub SM, Goepfert PA, Fusco DN, Malkin E, Bethony JM, Walsh EE, Graciaa DS, Samaha H, Sherman AC, Walsh SR, Abate G, Oikonomopoulou Z, El Sahly HM, Martin TCS, Kamidani S, Smith MJ, Ladner BG, Porterfield L, Dunstan M, Wald A, Davis T, Atmar RL, Mulligan MJ, Lyke KE, Posavad CM, Meagher MA, Stephens DS, Neuzil KM, Abebe K, Hill H, Albert J, Telu K, Mu J, Lewis TC, Giebeig LA, Eaton A, Netzl A, Wilks SH, Türeli S, Makhene M, Crandon S, Montefiori DC, Makowski M, Smith DJ, Nayak SU, Roberts PC, Beigel JH; COVAIL Study Group. Comparison of bivalent and monovalent SARS-CoV-2 variant vaccines: the phase 2 randomized open-label COVAIL trial. Nat Med. 2023 Sep;29(9):2334-2346.

Rouphael NG, Branche AR, Diemert DJ, Falsey AR, Losada C, Baden LR, Frey SE, Whitaker JA, Little SJ, Kamidani S, Walter EB, Novak RM, Rupp R, Jackson LA, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub SM, Goepfert PA, Fusco DN, Atmar RL, Posavad CM, Netzl A, Smith DJ, Telu K, Mu J, McQuarrie LJ, Makowski M, Makhene MK, Crandon S, Montefiori DC, Roberts PC, Beigel JH; Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team. Immunogenicity of a 2-Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial. J Infect Dis. 2023 Dec 20;228(12):1662-1666.

de Bruyn G, Wang J, Purvis A, Ruiz MS, Adhikarla H, Alvi S, Bonaparte MI, Brune D, Bueso A, Canter RM, Ceregido MA, Deshmukh S, Diemert D, Finn A, Forrat R, Fu B, Gallais J, Griffin P, Grillet MH, Haney O, Henderson JA, Koutsoukos M, Launay O, Torres FM, Masotti R, Michael NL, Park J, Rivera-Medina DM, Romanyak N, Rook C, Schuerman L, Sher LD, Tavares-Da-Silva F, Whittington A, Chicz RM, Gurunathan S, Savarino S, Sridhar S; VAT00002 booster cohorts study team. Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines: a phase 3, parallel-group study. EClinicalMedicine. 2023 Jul 22;62:102109. Tornberg H, Moezinia C, Wei C, Bernstein SA, Wei C, Al-Beyati R, Quan T, Diemert DJ. Assessment of the Dissemination of COVID-19-Related Articles Across Social Media: Altmetrics Study. JMIR Form Res. 2023 Jul 12;7:e41388.

Cohen KW, De Rosa SC, Fulp WJ, deCamp AC, Fiore-Gartland A, Mahoney CR, Furth S, Donahue J, Whaley RE, Ballweber-Fleming L, Seese A, Schwedhelm K, Geraghty D, Finak G, Menis S, Leggat DJ, Rahaman F, Lombardo A, Borate BR, Philiponis V, Maenza J, Diemert D, Kolokythas O, Khati N, Bethony J, Hyrien O, Laufer DS, Koup RA, McDermott AB, Schief WR, McElrath MJ. A first-in-human germline-targeting HIV nanoparticle vaccine induced broad and publicly targeted helper T cell responses. Sci Transl Med. 2023 May 24;15(697):eadf3309.

Branche AR, Rouphael NG, Losada C, Baden LR, Anderson EJ, Luetkemeyer AF, Diemert DJ, Winokur PL, Presti RM, Kottkamp AC, Falsey AR, Frey SE, Rupp R, Bäcker M, Novak RM, Walter EB, Jackson LA, Little SJ, Immergluck LC, Mahgoub SM, Whitaker JA, Babu TM, Goepfert PA, Fusco DN, Atmar RL, Posavad CM, Netzl A, Smith DJ, Telu K, Mu J, Makowski M, Makhene MK, Crandon S, Montefiori DC, Roberts PC, Beigel JH. Immunogenicity of the BA.1 and BA.4/BA.5 SARS-CoV-2 Bivalent Boosts: Preliminary Results from the COVAIL Randomized Clinical Trial. Clin Infect Dis. 2023 Apr 10:ciad209.

Diemert DJ, Correa-Oliveira R, Fraga CG, Talles F, Silva MR, Patel SM, Galbiati S, Kennedy JK, Lundeen JS, Gazzinelli MF, Li G, Hoeweler L, Deye GA, Bottazzi ME, Hotez PJ, El Sahly HM, Keitel WA, Bethony J, Atmar RL. A randomized, controlled Phase 1b trial of the Sm-TSP-2 Vaccine for intestinal schistosomiasis in healthy Brazilian adults living in an endemic area. PLoS Negl Trop Dis. 2023 Mar 30;17(3):e0011236. doi: 10.1371/journal.pntd.0011236.

deCamp AC, Corcoran MM, Fulp WJ, Willis JR, Cottrell CA, Bader DLV, Kalyuzhniy O, Leggat DJ, Cohen KW, Hyrien O, Menis S, Finak G, Ballweber-Fleming L, Srikanth A, Plyler JR, Rahaman F, Lombardo A, Philiponis V, Whaley RE, Seese A, Brand J, Ruppel AM, Hoyland W, Mahoney CR, Cagigi A, Taylor A, Brown DM, Ambrozak DR, Sincomb T, Mullen TM, Maenza J, Kolokythas O, Khati N, Bethony J, Roederer M, Diemert D, Koup RA, Laufer DS, McElrath JM, McDermott AB, Hedestam GBK, Schief WR. Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming. medRxiv [Preprint]. 2023 Mar 15:2023.03.10.23287126.

Garofano K, Rashid K, Smith M, Brantner C, Suwunnakorn S, Diemert D, Gordon O, Horvath A, Khan S, Popratiloff A, Rhim J, Sidahmed A, Maggirwar SB, O'Brien TJ, Perera MA, Lee NH. Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs. Sci Rep. 2023 Feb 17;13(1):2864.

Leggat DJ, Cohen KW, Willis JR, Fulp WJ, deCamp AC, Kalyuzhniy O, Cottrell CA, Menis S, Finak G, Ballweber-Fleming L, Srikanth A, Plyler JR, Schiffner T, Liguori A, Rahaman F, Lombardo A, Philiponis V, Whaley RE, Seese A, Brand J, Ruppel AM, Hoyland W, Yates NL, Williams LD, Greene K, Gao H, Mahoney CR, Corcoran MM, Cagigi A, Taylor A, Brown DM, Ambrozak DR, Sincomb T, Hu X, Tingle R, Georgeson E, Eskandarzadeh S, Alavi N, Lu D, Mullen TM, Kubitz M, Groschel B, Maenza J, Kolokythas O, Khati N, Bethony J, Crotty S, Roederer M, Karlsson Hedestam GB, Tomaras GD, Montefiori D, Diemert D, Koup RA, Laufer DS, McElrath MJ, McDermott AB, Schief WR. Vaccination induces HIV broadly neutralizing antibody precursors in humans. Science. 2022 Dec 2;378(6623):eadd6502.

Betouke Ongwe ME, Mouwenda YD, Stam KA, Kremsner PG, Lell B, Diemert D, Bethony J, Bottazzi ME, Hotez PJ, Leeuwen RV, Grobusch MP, Adegnika AA, Mayboroda OA, Yazdanbakhsh M. Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon. PLoS One. 2022 Sep 26;17(9):e0275013.

Diemert DJ, Zumer M, Campbell D, Grahek S, Li G, Peng J, Elena Bottazzi M, Hotez P, Bethony J. Safety and immunogenicity of the Na-APR-1 hookworm vaccine in infection-naïve adults. Vaccine. 2022 Oct 6;40(42):6084-6092. doi: 10.1016/j.vaccine.2022.09.017.

Branche AR, Rouphael NG, Diemert DJ, Falsey AR, Losada C, Baden LR, Frey SE, Whitaker JA, Little SJ, Anderson EJ, Walter EB, Novak RM, Rupp R, Jackson LA, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub SM, Goepfert PA, Fusco DN, Malkin E, Bethony JM, Walsh EE, Graciaa DS, Samaha H, Sherman AC, Walsh SR, Abate G, Oikonomopoulou Z, El Sahly HM, Martin TCS, Rostad CA, Smith MJ, Ladner BG, Porterfield L, Dunstan M, Wald A, Davis T, Atmar RL, Mulligan MJ, Lyke KE, Posavad CM, Meagher MA, Stephens DS, Neuzil KM, Abebe K, Hill H, Albert J, Lewis TC, Giebeig LA, Eaton A, Netzl A, Wilks SH, Türeli S, Makhene M, Crandon S, Lee M, Nayak SU, Montefiori DC, Makowski M, Smith DJ, Roberts PC, Beigel JH; COVAIL Study Group. SARS-CoV-2 Variant Vaccine Boosters Trial: Preliminary Analyses. medRxiv [Preprint]. 2022 Jul 15:2022.07.12.22277336.

Sridhar S, Joaquin A, Bonaparte MI, Bueso A, Chabanon AL, Chen A, Chicz RM, Diemert D, Essink BJ, Fu B, Grunenberg NA, Janosczyk H, Keefer MC, Rivera M DM, Meng Y, Michael NL, Munsiff SS, Ogbuagu O, Raabe VN, Severance R, Rivas E, Romanyak N, Rouphael NG, Schuerman L, Sher LD, Walsh SR, White J, von Barbier D, de Bruyn G, Canter R, Grillet MH, Keshtkar-Jahromi M, Koutsoukos M, Lopez D, Masotti R, Mendoza S, Moreau C, Ceregido MA, Ramirez S, Said A, Tavares-Da-Silva F, Shi J, Tong T, Treanor J, Diazgranados CA, Savarino S. Safety and immunogenicity of an AS03-adjuvanted SARS-CoV-2 recombinant protein vaccine (CoV2 preS dTM) in healthy adults: interim findings from a phase 2, randomised, dose-finding, multicentre study. Lancet Infect Dis. 2022 Jan 25:S1473-3099(21)00764-7.

Adewale B, Heintz JR, Pastore CF, Rossi HL, Hung LY, Rahman N, Bethony J, Diemert D, Babatunde JA, Herbert DR. Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. PLoS Negl Trop Dis. 2021 Oct 18;15(10):e0009550.

Mouwenda YD, Betouke Ongwe ME, Sonnet F, Stam KA, Labuda LA, De Vries S, Grobusch MP, Zinsou FJ, Honkpehedji YJ, Dejon Agobe JC, Diemert DJ, van Leeuwen R, Bottazzi ME, Hotez PJ, Kremsner PG, Bethony JM, Jochems SP, Adegnika AA, Massinga Loembe M, Yazdanbakhsh M. Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon. PLoS Negl Trop Dis. 2021 Oct 1;15(10):e0009732.

Pritchard DI, Diemert D, Bottazzi ME, Hawdon JM, Correa-Oliveira R, Bethony JM. Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development: The Human Hookworm Vaccination/Challenge Model (HVCM). Curr Top Microbiol Immunol. 2021 Jul 31.

Garofano K, Park CS, Alarcon C, Avitia J, Barbour A, Diemert D, Fraser CM, Friedman PN, Horvath A, Rashid K, Shaazuddin M, Sidahmed A, O'Brien TJ, Perera MA, Lee NH. Differences in the Platelet mRNA Landscape Portend Racial Disparities in Platelet Function and Suggest Novel Therapeutic Targets. Clin Pharmacol Ther. 2021 Sep;110(3):702-713.

Li G, Hoeweler L, Keegan B, Peng J, Scholte L, Hotez P, Bottazzi ME, Diemert D, Bethony J. Potency testing for a recombinant protein vaccine early in clinical development: Lessons from the?Schistosoma mansoni?Tetraspanin 2 vaccine. Vaccine X. 2021 Jun 6;8:100100.

Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, Diemert D, Spector SA, Rouphael N, Creech CB, McGettigan J, Khetan S, Segall N, Solis J, Brosz A, Fierro C, Schwartz H, Neuzil K, Corey L, Gilbert P, Janes H, Follmann D, Marovich M, Mascola J, Polakowski L, Ledgerwood J, Graham BS, Bennett H, Pajon R, Knightly C, Leav B, Deng W, Zhou H, Han S, Ivarsson M, Miller J, Zaks T; COVE Study Group. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med. 2021 Feb 4;384(5):403-416.

Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agobé JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, van Leeuwen R, Molemans M, Kremsner PG, Yazdanbakhsh M, Hotez PJ, Bottazzi ME, Li G, Bethony JM, Diemert DJ†, Grobusch MP†; HookVac Consortium. Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. Lancet Infect Dis. 2021 Feb; 21(2):275-285. †Co-Senior Authors.

Keitel WA, Potter GE, Diemert D, Bethony J, El Sahly HM, Kennedy JK, Patel SM, Plieskatt JL, Jones W, Deye G, Bottazzi ME, Hotez PJ, Atmar RL. A phase 1 study of the safety, reactogenicity, and immunogenicity of a Schistosoma mansoni vaccine with or without glucopyranosyl lipid A aqueous formulation (GLA-AF) in healthy adults from a non-endemic area. Vaccine. 2019 Sep 9.

Hotez PJ, Bottazzi ME, Bethony JM, Diemert D. Advances in the Development of a Human Schistosomiasis Vaccine. Trends Parasitol. 2018 Nov 16.

Diemert DJ, Bottazzi ME, Plieskatt J, Hotez PJ, Bethony JM. Lessons along the Critical Path: Developing Vaccines against Human Helminths. Trends Parasitol. 2018 Jul 28. pii: S1471-4922(18)30143-0.

Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open Forum Infect Dis. 2018 Apr 19;5(5):ofy083.

Baay MFD, Richie TL, Neels P; Session chairs at the second Human Challenge Trials meeting (Cavaleri M, Chilengi R, Diemert D, Hoffman SL, Johnson R, Kirkpatrick BD, Knezevic I, Laurens M, McShane H, Njuguna P, Older Aguilar A, Pollard AJ, Riddle M, Sauerwein R, Southern J, Tribble D, Wildfire)., Human challenge trials in vaccine development, Rockville, MD, USA, September 28-30, 2017, Biologicals, 2018 Mar.

Diemert D, Freire J, Valente V, Fraga G, Talles F, Grahek S, Campbell D, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira O, Hotez P, Bethony J. Safety and Immunogenicity of the Na-GST-1 Hookworm Vaccine in Brazilian and American Adults. PLOS Negl Trop Dis. 2017 May 2;11(5):e0005574.

Brelsford JB, Plieskatt JL, Yakovleva A, Li G, Keegan BP, Jariwala A, Peng J, Xia P, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Bethony JM, Diemert D. Advances in Neglected Tropical Disease Vaccines: Developing Relative Potency and Functional Assays for the Na-GST-1/Alhydrogel Hookworm Vaccine. PLoS Negl Trop Dis. 2017 Feb 13;11(2):e0005385.

Diemert DJ, Lobato L, Styczynski A, Zumer M, Soares A, Gazzinelli MF. A Comparison of the Quality of Informed Consent for Clinical Trials of an Experimental Hookworm Vaccine Conducted in Developed and Developing Countries. PLoS Negl Trop Dis. 2017 Jan 23;11(1):e0005327.

Loukas A, Hotez PJ, Diemert D, Yazdanbakhsh M, McCarthy JS, Correa-Oliveira R, Croese J, Bethony JM. Hookworm infection. Nat Rev Dis Primers. 2016 Dec 8;2:16088.

Bartsch SM, Hotez PJ, Asti L, Zapf KM, Bottazzi ME, Diemert DJ, Lee BY. The Global Economic and Health Burden of Human Hookworm Infection. PLoS Negl Trop Dis. 2016 Sep 8;10(9):e0004922.

Gazzinelli MF, Lobato L, Andrade G, Matoso LF, Diemert DJ, Gazzinelli A. Improving the understanding of schistosomiasis among adolescents in endemic areas in Brazil: A comparison of educational methods. Patient Educ Couns. 2016 Oct;99(10):1657-62.

Bartsch SM, Hotez PJ, Hertenstein DL, Diemert DJ, Zapf KM, Bottazzi ME, Bethony JM, Brown ST, Lee BY. Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting. Vaccine. 2016 Apr 27;34(19):2197-206.

Periago MV, Diniz RC, Pinto SA, Yakovleva A, Correa-Oliveira R, Bethony JM, Diemert DJ. The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths. PLoS Negl Trop Dis. 2015 Aug 4;9(8):e0003967.

Blair P, Diemert D. Update on prevention and treatment of intestinal helminth infections. Curr Infect Dis Rep. 2015 Mar;17(3):465.

Lobato L, Bethony JM, Pereira FB, Grahek SL, Diemert D, Gazzinelli MF. Impact of gender on the decision to participate in a clinical trial: a cross-sectional study. BMC Pub Health 2014. Nov 6;14:1156.

Saichua P, Sithithaworn P, Jariwala AR, Diemert DJ, Sithithaworn J, Sripa B, Laha T, Mairiang E, Pairojkul C, Khuntikeo N, Mulvenna J, Bethony JM. Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. PLoS Negl Trop Dis 2013 May 23;7(5):e2228.

Diemert D, Hotez P, Bacon KM, Beaumier C, Bethony JM, Bottazzi ME, Brooker S, Couto AR, da Silva Freire M, Homma A, Lee BY, Loukas A, Loblack M, Morel CM, Correa Oliveira R, Russell PK. The Human Hookworm Vaccine. Vaccine. 2013 Apr 18;31 Suppl 2:B227-32.

Geiger SM, Jardim-Botelho A, Williams W, Diemert D, Alexander N, Bethony JM. Serum CCL11 (eotaxin) and CCL17 (TARC) are serological indicators for multiple helminth infections and are driven by Schistosoma mansoni infection in humans. Trop Med Int Health. 2013;18(6):750-760.

Diemert DJ, Pinto AG, Freire J, Jariwala A, Santiago H, Hamilton RG, Periago MV, Loukas A, Tribolet L, Mulvenna J, Correa-Oliveira R, Hotez PJ, Bethony JM. Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths. J Allergy Clin Immunol. 2012 Jul;130(1):169-176.

Pearson MS, Tribolet L, Cantacessi C, Periago MV, Valerio MA, Jariwala AR, Hotez P, Diemert D, Loukas A, Bethony J. Molecular mechanisms of hookworm disease: Stealth, virulence, and vaccines. J Allergy Clin Immunol. 2012 Jul;130(1):13-21.

Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug- Sep;34(8-9):404-11.

Schneider B, Jariwala AR, Periago MV, Gazzinelli MF, Bose SN, Hotez PJ, Diemert DJ, Bethony JM. A history of hookworm vaccine development. Hum Vaccin 2011;7(11):1234-1244.

Geiger SM, Alexander N, Fujiwara RT, Brooker S, Cundill B, Diemert DJ, Corrêa- Oliveira R, Bethony JM. Necator americanus and helminth co-infections: further down-modulation of hookworm-specific type 1 immune responses. PLoS Negl Trop Dis 2011;5(9):e1280.

Cundill B, Alexander N, Bethony JM, Diemert D, Pullan RL, Brooker S. Rates and intensity of re-infection with human helminths after treatment and the influence of individual, household, and environmental factors in a Brazilian community. Parasitol 2011 Sep;138(11):1406-16.

Alexander N, Cundill B, Sabatelli L, Bethony JM, Diemert D, Hotez P, Smith PG, Rodrigues LC, Brooker S. Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. Vaccine 2011; 29(20):3686-94.

Hotez PJ, Bethony JM, Diemert DJ, Pearson M, Loukas A. Developing vaccines to combat hookworm infection and intestinal schistosomiasis. Nature Reviews Microbiology (2010); 8: 814-26.

Jariwala AR, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Periago MV, Bottazzi ME, Hotez PJ, Bethony JM. Potency testing for the experimental Na- GST-1 hookworm vaccine. Expert Reviews of Vaccines (2010); 9: 1219-30.

Gazzinelli MF, Lobato L, Matoso L, Avila R, Marques RD, Brown AS, Correa- Oliveira R, Bethony JM, Diemert, DJ. Health education through analogies: preparation of a community for clinical trials of a vaccine against hookworm in an endemic area of Brazil. PLoS Negl Trop Dis (2010); 4(7):e749.

Bethony JM, Diemert DJ, Oliveira SC, Loukas A. Can schistosomiasis really be consigned to history without a vaccine? Vaccine (2008); 26(27-28):3373-6.

Miura K, Zhou H, Moretz SE, Diouf A, Thera MA, Dolo A, Doumbo O, Malkin E, Diemert D, Miller LH, Mullen GED, Long CA. Comparison of Biological Activity of Human Anti-Apical Membrane Antigen-1 Antibodies Induced by Natural Infection and Vaccination. J Immunol (2008); 181: 8776-8783.

Duan J, Mu J, Thera MA , Joy D, Kosakovsky-Pond SL, Diemert D, Long C, Zhou H, Miura K, Ouattara A, Dolo A, Doumbo OK, Su X, Miller LH. Population structure of the genes encoding the polymorphic P. falciparum apical membrane antigen1: implications for vaccine design. PNAS (2008); 105(22):7857-62

Jardim-Botelho A, Raff S, Rodrigues R, Hoffman HJ, Diemert DJ, Correa-Oliveira R, Bethony JM, Gazzinelli MF. Hookworm, A. lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren. Trop Med Int Health (2008); 13(8):994-1004.

Bethony JM, Simon G, Diemert DJ, Parenti D, Desrosiers A, Schuck S, Fujiwara R, Santiago H, Hotez PJ. Randomized, Placebo-controlled, Double-blind Trial of the Na-ASP-2 Hookworm Vaccine in Unexposed Adults. Vaccine (2008); 26(19):2408-17.

Jardim-Botelho A, Brooker B, Geiger SM, Fleming F, Lopes ACS, Diemert DJ, Correa-Oliveira R, Bethony JM. Age patterns in undernutrition and helminth infection in as rural area of Brazil. Trop Med Int Health (2008); 13(4):458-67.

Diemert DJ, Bethony JM, Hotez PJ. Hookworm Vaccines. Clin Infect Dis. (2008); 46:282-288

Industry Relationships and Collaborations

This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.

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