Assistant Research Professor of Anatomy and Cell Biology
Office Phone: 202-994-5545
Department: Anatomy and Cell Biology
- D.D.S. equivalent, Universidade Federal de Alfenas - UNIFAL/EFOA, 2000
- Masters in Cell Biolgy, Universidade Federal de Minas Gerais - UFMG, 2004
- Ph.D. in Cell Biology, Universidade Federal de Minas Gerais - UFMG, 2007
Dr. Tavares has training in dentistry and expertise in the field of developmental biology, with emphasis in cardiovascular and craniofacial biology and development. During his Masters and Ph.D. studies, he received broad training in anatomy, histology and cell biology. For the execution of his Ph.D. dissertation, he received a highly competitive grant award from the Brazilian government to travel abroad and work in the laboratory of Dr. Raymond Runyan at the University of Arizona where he later became a postdoctoral research scholar. Because of his training in dentistry, Dr Tavares started a second post-doctoral fellowship in the laboratory of Dr. David Clouthier at the University of Colorado Anschutz Medical Campus. There, he studied normal and abnormal craniofacial development by working with different transgenic mouse lines and different cell lines relevant to craniofacial development. Currently Dr. Tavares is an assistant research professor at the George Washington University where he studies the genetic causes of craniofacial birth defects by studying normal and abnormal jaw and ear development using different animal models (mouse and Xenopus) and culture of neural crest cells.
Dr. Tavares’ research is focused on the analysis of the genetic causes of craniofacial birth defects by describing normal and abnormal jaw and ear development using the mouse and Xenopus models. Currently we are trying to uncover novel genes that are causative to branchio-oto-renal syndrome (BOR) and related to the transcription factor Six1 and its co-factor Eya1 by using transcriptome analysis and in vitro culture of neural crest cells. Dr. Tavares' also teaches histology and embryology to undergraduates and med students. He tries to engage students by using techniques that motivates learning.
Tavares, E. P.; TAVARES, A.L.; Florio, F.M. The impact of technological endodontic resources on the training of the general dentist. European Journal of Dental Education. 2020. Under review.
Shah, A.M.; Krohn, P.; Baxi, A.B.; TAVARES, A.L.; Sulllivan, C.H.; Chillakuru, Y.R.; Majumdar, H.D.; Neilson, K.M.; Moody, S.A. Six1 proteins with human Branchio-Oto-Renal mutations differentially affect cranial gene expression and otic development. Disease, Models & Mechanisms. 2020. PMID: 31980437
Maynard, T.; Horvarth, A.; Bernout, J.; Karpinski, B.; TAVARES, A.L.; Shah, A.; Zheng, Q.; Spurr, L.; Olender, J.; Moody, S.A.; Fraser, C.M.; LaMantia, A.; Lee, N.H. Transcriptional dysregulation in developing trigeminal sensory neurons in the LgDel mouse model of DiGeorge 22q11.2 Deletion Syndrome. Human Molecular Genetics. 2020. PMID: 32047912
Pritchard, A.B.; Kanai, S.M.; Krock, B.; Schindwolf, E.; Oliver-Krasinski, J.; Kahlek, N.; Okashah, N.; Lambert, N.A.; TAVARES, A.L.; Zackai, E.; Clouthier, D.E. Loss-of-Function of Endothelin Receptor Type A results in Oro-Oto-Cardiac Syndrome. The American Journal of Medical Genetics, 2020. PMID: 32133772
TAVARES, A.L.; Brown, J.A.; Ulrich, E.C.; Dvorak, K.; Runyan, R.B. Runx2-I is an early regulator of epithelial-mesenchymal cell transition in the chick embryo. Developmental Dynamics, v.247, n.3, p.542 – 554, 2018. PMID: 28631378
TAVARES, A.L.; Cox, T.C.; Maxson, R.M.; Ford, H.; Clouthier, D.E. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development, v.144, n.11, p.2021 – 2031, 2017. PMID: 28455376
Iklé, J. M.; TAVARES, A.L.; King, M.; Ding, H.; Colombo, S.; Firulli, B.A.; Firulli, A.B.; Targoff, K.L.; Yelon, D.; Clouthier, D.E. Nkx2.5 regulates Endothelin Converting Enzyme-1 during pharyngeal arch patterning. Genesis, v.55, n.3, p.1-16, 2017. PMID: 28109039
TAVARES, A.L., Artinger, K.B., Clouthier, D.E. Regulating craniofacial development at the 3’ end; MicroRNAs and their function in facial morphogenesis. Current Topics in Developmental Biology. Craniofacial Development. Elsevier, v.115, p.335 – 375, 2015. PMID: 26589932
Cox, C.M., Mandell, E.K., Stewart, L., Lu, R., Johnson, D.L., McCarter, S.D., TAVARES, A., Runyan, R., Ghosh, S., Wilson, J.M. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Mol Biol Cell., v.26, n.14, p.2673 – 2684, 2015. PMID: 25995376
Gordon, C.T.; Weave K.N., Zechi-Ceide, R.M., Madsen, E.C., TAVARES, A.L. (equal contribution) et al. Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. The American Journal of Human Genetics, v.96, n.4, p.519 – 531, 2015. PMID: 25772936
TAVARES, A.L.; Clouthier, D.E. Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders. Developmental Biology, v.400, n.2, p.191 – 201, 2015. PMID: 25725491
Clouthier, D.E., Passos-Bueno, M.R., TAVARES, A.L., Lyonnet, S., Amiel, J., Gordon, C.T. Understanding the basis of auriculocondylar syndrome: Insights from human, mouse and zebrafish genetic studies. Am J Med Genet C Semin Med Genet., v.163C, n.4, p.306 – 317, 2013. PMID: 24123988
TAVARES, A.L., Garcia, E.L., Kuhn, K., Woods, C.M., Williams, T., Clouthier, D.E. Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Developmental Biology, v.371, n.1, p.47 – 56, 2012. PMID: 22902530
Lencinas, A., TAVARES, A.L., Barnett, J.V., Runyan, R.B. Collagen Gel Analysis of Epithelial-Mesenchymal Transition in the Embryo Heart: An in vitro Model System for the Analysis of Tissue Interaction, Signal Transduction and Environmental Effects. Birth Defects Research Part C, v.93, n.4, p.298 – 311, 2011. PMID: 22271679
Oliveira, G.V., Hawkins, H.K., Chinkes, D., Burke, A., TAVARES A.L., Ramos-e-Silva M, Albrecht TB, Kitten GT, Herndon DN. Hypertrophic versus non hypertrophic scars compared by immunohistochemistry and laser confocal microscopy: type I and III collagens. International Wound Journal, v.6, n.6, p.445 – 52, 2009. PMID: 20051096
O'Connell, D.J., Molinar, A.J., TAVARES, A.L., Mathine, D.L., Runyan, R.B., Bahl, J.J. Transfection of cells attached to selected cell based biosensor surfaces. Life Sciences, v.80, n.15, p.1395 - 1402, 2007. PMID: 17261315
TAVARES, A.L., Mercado-Pimentel, M.E., Runyan, R.B., Kitten, G.T. TGFbeta-mediated RhoA expression is necessary for epithelial-mesenchymal transition in the embryonic chick heart. Developmental Dynamics, v.235, n.6, p.1589 - 1598, 2006. PMID: 16598712
Santos, S.N., Oliveira G.V., TAVARES, A.L., Massensini A.R., Carvalhaes, L.S., Reljasvaara R., Kitten, G.T. Collagen XVIII and fibronectin involvement in bullous scleroderma. Dermatology Online Journal, v.1, n.11, p.17 - 17, 2005. PMID: 15748558
Industry Relationships and Collaborations
This faculty member (or a member of their immediate family) has reported a financial interest with the health care related companies listed below. These relations have been reported to the University and, when appropriate, management plans are in place to address potential conflicts.